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1. (WO2019042247) PHARMACEUTICAL COMPOSITION OF CYP17 INHIBITOR AND PREPARATION METHOD THEREFOR
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Pub. No.: WO/2019/042247 International Application No.: PCT/CN2018/102492
Publication Date: 07.03.2019 International Filing Date: 27.08.2018
IPC:
A61K 9/20 (2006.01) ,A61K 31/58 (2006.01) ,A61K 47/18 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
58
containing heterocyclic rings, e.g. aldosterone, danazol, stanozolol, pancuronium, digitogenin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
16
containing nitrogen
18
Amines; Quaternary ammonium compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
江苏恒瑞医药股份有限公司 JIANGSU HENGRUI MEDICINE CO., LTD. [CN/CN]; 中国江苏省连云港市 经济技术开发区昆仑山路7号 No.7 Kunlunshan Road, Economic and Technological Development Zone Lianyungang, Jiangsu 222047, CN
Inventors:
王捷 WANG, Jie; CN
王伟 WANG, Wei; CN
钱雯 QIAN, Wen; CN
张凤娥 ZHANG, Fenge; CN
Agent:
上海弼兴律师事务所 SHANGHAI BESHINING LAW OFFICE; 中国上海市 小木桥路681号外经大厦21楼 21st Floor SFECO Mansion 681 Xiaomuqiao Road Shanghai 200032, CN
Priority Data:
201710750827.828.08.2017CN
201710758825.329.08.2017CN
201810205415.013.03.2018CN
Title (EN) PHARMACEUTICAL COMPOSITION OF CYP17 INHIBITOR AND PREPARATION METHOD THEREFOR
(FR) COMPOSITION PHARMACEUTIQUE D’INHIBITEUR DE CYP17 ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 一种CYP17抑制剂的药物组合物及其制备方法
Abstract:
(EN) A pharmaceutical composition of a CYP17 inhibitor and a preparation method therefor. The composition comprises 17-(3-pyridyl)androstane-5,16-diene-3b-alcohol or a derivative thereof, and an absorption enhancer, such as N-(8-(2-hydroxyl benzoyl)amino) caprylate (NAC). The composition has improved bioavailability, and can alleviate individual differences of patients to which drugs are delivered.
(FR) La présente invention concerne une composition pharmaceutique d’un inhibiteur de CYP17 et son procédé de préparation. La composition comprend du 17-(3-pyridyl)androstane-5,16-diène-3b-alcool ou un dérivé de celui-ci, et un activateur d’absorption, tel que le N-(8-(2-hydroxylbenzoyl)amino)caprylate (NAC). La composition présente une biodisponibilité améliorée, et peut atténuer des différences individuelles de patients auxquels des médicaments sont administrés.
(ZH) 一种CYP17抑制剂的药物组合物及其制备方法。所述组合物含有17-(3-吡啶基)雄甾-5,16-二烯-3b-醇或其衍生物,和吸收促进剂,如N-(8-(2-羟基苯甲酰基)氨基)辛酸(NAC)盐。所述组合物具有提高的生物利用度,并能改善给药患者个体差异性。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)