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1. (WO2019042153) RECOMBINANT BISPECIFIC ANTIBODY
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Pub. No.: WO/2019/042153 International Application No.: PCT/CN2018/100971
Publication Date: 07.03.2019 International Filing Date: 17.08.2018
IPC:
C07K 16/46 (2006.01) ,C12N 15/13 (2006.01) ,A61K 39/395 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46
Hybrid immunoglobulins
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
12
Genes encoding animal proteins
13
Immunoglobulins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
四川科伦博泰生物医药股份有限公司 SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. [CN/CN]; 中国四川省成都市 温江区海峡两岸科技产业开发园区新华大道二段666号 No. 666, Xinhua Avenue (Section 2) Hai Xia Industrial Park, Wenjiang District Chengdu, Sichuan 611138, CN
Inventors:
薛彤彤 XUE, Tongtong; CN
肖亮 XIAO, Liang; CN
刘登念 LIU, Dengnian; CN
龙虎 LONG, Hu; CN
胡江江 HU, Jiangjiang; CN
崔亚敏 CUI, Yamin; CN
袁晓曦 YUAN, Xiaoxi; CN
王利春 WANG, Lichun; CN
王晶翼 WANG, Jingyi; CN
Agent:
北京市柳沈律师事务所 LIU, SHEN & ASSOCIATES; 中国北京市 海淀区彩和坊路10号1号楼10层 10th Floor, Building 1 10 Caihefang Road, Haidian District Beijing 100080, CN
Priority Data:
201710781402.301.09.2017CN
Title (EN) RECOMBINANT BISPECIFIC ANTIBODY
(FR) ANTICORPS BISPÉCIFIQUE RECOMBINANT
(ZH) 重组双特异性抗体
Abstract:
(EN) Provided are a recombinant bispecific antibody against CTLA-4 and PDL-1, a nucleic acid molecule for encoding the antibody, a vector and a host cell comprising the nucleic acid molecule, and a method for preparing the antibody. Also provided are a pharmaceutical composition comprising the bispecific antibody, and usage of the bispecific antibody in preparation of the pharmaceutical composition.
(FR) L'invention concerne un anticorps bispécifique recombinant dirigé contre CTLA-4 et PDL-1, une molécule d'acide nucléique pour coder l'anticorps, un vecteur et une cellule hôte comprenant la molécule d'acide nucléique, et un procédé de préparation de l'anticorps. L'invention concerne également une composition pharmaceutique comprenant l'anticorps bispécifique, et l'utilisation de l'anticorps bispécifique dans la préparation de la composition pharmaceutique.
(ZH) 提供了一种针对CTLA-4和PDL-1的重组双特异性抗体,编码抗体的核酸分子,包含该核酸分子的载体和宿主细胞,以及制备该抗体的方法。还提供了包含该双特异性抗体的药物组合物、以及该双特异性抗体在制备药物组合物中的用途。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)