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1. (WO2019042108) SELENIUM-DOPED BLACK PHOSPHORUS PRODRUG AND PREPARATION METHOD THEREFOR
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Pub. No.: WO/2019/042108 International Application No.: PCT/CN2018/099567
Publication Date: 07.03.2019 International Filing Date: 09.08.2018
IPC:
A61K 33/04 (2006.01) ,A61K 47/59 (2017.01) ,A61K 47/04 (2006.01) ,A61K 41/00 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
04
Sulfur, selenium or tellurium; Compounds thereof
[IPC code unknown for A61K 47/59]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
02
Inorganic compounds
04
Non-metals; Compounds thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41
Medicinal preparations obtained by treating materials with wave energy or particle radiation
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
深圳大学 SHENZHEN UNIVERSITY [CN/CN]; 中国广东省深圳市 南山区南海大道3688号 Nanhai Ave 3688, Nanshan District Shenzhen, Guangdong 518055, CN
Inventors:
张晗 ZHANG, Han; CN
仇萌 QIU, Meng; CN
Agent:
广州三环专利商标代理有限公司 SCIHEAD IP LAW FIRM; 中国广东省广州市 越秀区先烈中路80号汇华商贸大厦1508室 Room 1508, Huihua Commercial & Trade Building No. 80, Xianlie Zhong Road, Yuexiu Guangzhou, Guangdong 510070, CN
Priority Data:
201710754749.929.08.2017CN
Title (EN) SELENIUM-DOPED BLACK PHOSPHORUS PRODRUG AND PREPARATION METHOD THEREFOR
(FR) PROMÉDICAMENT À BASE DE PHOSPHORE NOIR DOPÉ AU SÉLÉNIUM ET PROCÉDÉ DE PRÉPARATION ASSOCIÉ
(ZH) 一种硒掺杂黑磷前药及其制备方法
Abstract:
(EN) Disclosed is a selenium-doped black phosphorus prodrug comprising selenium-doped black phosphorus nanosheets and polyethylene glycol amine coating the surface of the selenium-doped black phosphorus nanosheets. The selenium-doped black phosphorus nanosheets comprise black phosphorus nanosheets and selenium elements doped in the black phosphorus nanosheets, with the selenium elements replacing positions of a portion of the phosphorus atoms in the black phosphorus crystal lattice. The selenium-doped black phosphorus prodrug is a controlled-release prodrug of selenium elements, which can realize the near-infrared light controlled-release of selenium elements, thereby controllably regulating selenium content in the human body, regulating human immunity, and preventing and treating cancers. Also provided is a method for preparing the selenium-doped black phosphorus prodrug.
(FR) L'invention concerne un promédicament à base de phosphore noir dopé au sélénium comprenant des nanofeuilles de phosphore noir dopé au sélénium et une polyéthylèneglycolamine revêtant la surface des nanofeuilles de phosphore noir dopé au sélénium. Les nanofeuilles de phosphore noir dopé au sélénium comprennent des nanofeuilles de phosphore noir et des éléments de sélénium dopés dans les nanofeuilles de phosphore noir, les éléments de sélénium remplaçant les positions d'une partie des atomes de phosphore dans le réseau cristallin de phosphore noir. Le promédicament à base de phosphore noir dopé au sélénium est un promédicament à libération contrôlée d'éléments de sélénium, qui permet de réaliser la libération contrôlée par la lumière proche infrarouge d'éléments de sélénium, ce qui permet de réguler de manière contrôlée la teneur en sélénium dans le corps humain, de réguler l'immunité humaine et de prévenir et de traiter des cancers. L'invention concerne également un procédé de préparation du promédicament à base de phosphore noir dopé au sélénium.
(ZH) 一种硒掺杂黑磷前药,包括硒掺杂黑磷纳米薄片和包覆在所述硒掺杂黑磷纳米薄片表面的聚乙二醇胺,所述硒掺杂黑磷纳米薄片包括黑磷纳米薄片和掺杂在所述黑磷纳米薄片中的硒元素,所述硒元素取代了黑磷晶格中部分磷原子的位置。该硒掺杂黑磷前药用于硒元素可控释放前药,可实现硒元素的近红外光可控释放,从而可控地调节人体中硒含量,调节人体免疫力,预防和治疗癌症。还提供了该硒掺杂黑磷前药的制备方法。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)