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1. (WO2019041799) HYDROGEL FOR REPAIRING TISSUE INJURY AND PREPARATION METHOD THEREFOR
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Pub. No.: WO/2019/041799 International Application No.: PCT/CN2018/080831
Publication Date: 07.03.2019 International Filing Date: 28.03.2018
IPC:
A61K 9/06 (2006.01) ,A61K 31/5575 (2006.01) ,A61K 47/36 (2006.01) ,A61K 47/42 (2017.01) ,A61P 17/02 (2006.01) ,A61P 29/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
06
Ointments; Bases therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
557
Eicosanoids, e.g. leukotrienes
5575
having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
42
Proteins; Polypeptides; Degradation products thereof; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
02
for treating wounds, ulcers, burns, scars, keloids, or the like
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
天津昂赛细胞基因工程有限公司 TIANJIN AMCELLGENE ENGINEERING CO., LTD. [CN/CN]; 中国天津市 天津经济技术开发区第四大街80号天大科技园B3座 Bld. B3 Tianda Science & Technology Park No. 80 the Fourth Street, TEDA Tianjin 300457, CN
Inventors:
李宗金 LI, Zongjin; CN
张帅强 ZHANG, Shuaiqiang; CN
韩之波 HAN, Zhibo; CN
Agent:
天津市北洋有限责任专利代理事务所 BEI & OCEAN; 中国天津市 南开区鞍山西道时代公寓A座603室 Bld. A Ste 603, Time Plaza West An-shan Road, Nankai District Tianjin 300193, CN
Priority Data:
201710752030.128.08.2017CN
Title (EN) HYDROGEL FOR REPAIRING TISSUE INJURY AND PREPARATION METHOD THEREFOR
(FR) HYDROGEL POUR RÉPARER UNE LÉSION TISSULAIRE ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 一种用于组织损伤修复的水凝胶及制备方法
Abstract:
(EN) Disclosed in the present invention are hydrogel for repairing tissue injury and a preparation method therefor. The preparation method comprises the following steps: dissolving a hydrogel material with sterile distilled water for swelling to obtain hydrogel; dissolving PGE2 powder into a phosphate buffer solution to prepare a PGE2 solution; dropwise adding the PGE2 solution to the hydrogel, and performing stirring at a temperature of 2-8°C for 3-5 hours; and storing or freeze-storing the product, the PGE2 being the abbreviation of prostaglandin E2. The hydrogel of the present invention can extend the release time of the PGE2 to a certain extent, is directly applicable to the treatment of tissue injury, and is capable of promoting the recovery of injured skin tissue and functions. The hydrogel is capable of inducing macrophage at an injured site to polarize to M2 type so as to inhibit inflammation, thereby accelerating the healing of injury and promoting angiogenesis at the injured part in early stage. In addition, the hydrogel of the present invention has no cytotoxicity, can be directly applied to a wound surface, is convenient to use and low in price, and has an effective therapeutic effect.
(FR) La présente invention concerne un hydrogel pour réparer une lésion tissulaire et son procédé de préparation. Le procédé de préparation comprend les étapes suivantes consistant à : dissoudre un matériau d'hydrogel avec de l'eau distillée stérile pour qu'il gonfle et pour obtenir un hydrogel ; dissoudre la poudre de PGE2 dans une solution tampon de phosphate pour préparer une solution de PGE2 ; ajouter goutte à goutte la solution de PGE2 à l'hydrogel, et à effectuer une agitation à une température de 2 à 8 °C pendant 3 à 5 heures ; et à stocker ou à lyophiliser le produit, la PGE2 étant l'abréviation de prostaglandine E2. L'hydrogel de la présente invention peut prolonger le temps de libération de la PGE2 dans une certaine mesure, est directement applicable au traitement d'une lésion tissulaire, et est capable de favoriser la récupération de tissu et de fonctions cutanés blessés. L'hydrogel est capable d'induire un macrophage au niveau d'un site blessé pour polariser le type M2 de façon à inhiber l'inflammation, ce qui permet d'accélérer la guérison d'une lésion et de favoriser l'angiogenèse au niveau de la partie blessée à un stade précoce. De plus, l'hydrogel de la présente invention ne présente pas de cytotoxicité, peut être directement appliqué à la surface d'une plaie, est pratique à utiliser et peu coûteuse, et a un effet thérapeutique efficace.
(ZH) 本发明公开了一种用于组织损伤修复的水凝胶及制备方法,其制备方法包括如下步骤:使用无菌蒸馏水溶解水凝胶材料,溶胀,获得水凝胶;将PGE2粉末溶于磷酸盐缓冲液中制成PGE2溶液,将PGE2溶液滴加到水凝胶中,在2-8℃条件下,搅拌3-5小时;保存或冻存,所述PGE2为前列腺素E2的简写。本发明的水凝胶能够一定程度的延长PGE2的释放时间,直接用于组织损伤的治疗,可以促进损伤皮肤组织学和功能学的恢复。可以诱导损伤位点巨噬细胞向M2型极化抑制炎症反应,加速了损伤的愈合,并在早期促进了损伤部位的血管新生。此外,本发明的水凝胶无细胞毒性,可直接涂抹于创伤表面,使用方便,价格低廉,并具有有效的治疗作用。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)