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1. (WO2019041689) IMPRINTED GENE GRADING MODEL FOR COLORECTAL TUMOURS AND SYSTEM COMPOSED OF SAME
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Pub. No.: WO/2019/041689 International Application No.: PCT/CN2017/118956
Publication Date: 07.03.2019 International Filing Date: 27.12.2017
IPC:
C12Q 1/68 (2018.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
立森印迹诊断技术(无锡)有限公司 LISEN IMPRINTING DIAGNOSTICS WUXI CO., LTD. [CN/CN]; 中国江苏省无锡市 新吴区清源路20号立业楼B座5层 5th Floor, Liye Building B No. 20 Qingyuan Road, Xinwu District Wuxi, Jiangsu 214000, CN
Inventors:
成彤 CHENG, Tong; CN
周宁 ZHOU, Ning; CN
Agent:
北京品源专利代理有限公司 BEYOND ATTORNEYS AT LAW; 中国北京市 海淀区莲花池东路39号西金大厦6层 F6, Xijin Centre 39 Lianhuachi East Road, Haidian District Beijing 100036, CN
Priority Data:
201710774223.731.08.2017CN
Title (EN) IMPRINTED GENE GRADING MODEL FOR COLORECTAL TUMOURS AND SYSTEM COMPOSED OF SAME
(FR) MODÈLE DE NOTATION DE GÈNE IMPRIMÉ POUR LES TUMEURS COLORECTALES ET SYSTÈME COMPOSÉ DE CE DERNIER
(ZH) 用于结直肠肿瘤的印记基因分级模型及其组成的系统
Abstract:
(EN) Provided in the present application are an imprinted gene grading model for colorectal tumours and a system composed of same, the model grading the change of an imprinted gene in colorectal tumours by means of calculating the expression amount of imprinted gene deletion and the expression amount of abnormal imprinted gene copy numbers, the imprinted gene being any one or a combination of at least two of Z1, Z2, Z3, or Z4, the imprinted gene Z1 being Gnas, the imprinted gene Z2 being Igftr, the imprinted gene Z3 being Mest, and the imprinted gene Z4 being Plagl1.
(FR) La présente invention concerne un modèle de notation de gène imprimé pour les tumeurs colorectales et un système composé de ce dernier, le modèle notant le changement d’un gène imprimé dans les tumeurs colorectales à l’aide du calcul de la quantité d’expression de la délétion de gène imprimé et la quantité d’expression des nombres de copies de gènes imprimés anormaux, le gène imprimé étant n’importe lequel ou une combinaison d’au moins deux de Z1, Z2, Z3, ou Z4, le gène imprimé Z1 étant Gnas, le gène imprimé Z2 étant Igftr, le gène imprimé Z3 étant Mest, et le gène imprimé Z4 étant Plagl1.
(ZH) 本申请提供了用于结直肠肿瘤的印记基因分级模型及其组成的系统,所述模型通过计算印记基因缺失表达量和印记基因拷贝数异常表达量对印记基因在结直肠肿瘤中的变化进行分级,其中,所述印记基因为Z1、Z2、Z3或Z4中的任意一个或至少两个的组合,所述印记基因Z1为Gnas,所述印记基因Z2为Igf2r,所述印记基因Z3为Mest,所述印记基因Z4为Plagl1。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)