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1. (WO2019041599) APPLICATION OF GPR18 AND REGULATOR THEREOF IN PREVENTION AND TREATMENT OF IMMUNE SYSTEM DISEASES
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Pub. No.: WO/2019/041599 International Application No.: PCT/CN2017/113544
Publication Date: 07.03.2019 International Filing Date: 29.11.2017
IPC:
A61K 31/09 (2006.01) ,A61K 31/131 (2006.01) ,A61K 31/133 (2006.01) ,A61P 1/00 (2006.01) ,A61P 25/00 (2006.01) ,A61P 37/00 (2006.01) ,A61P 37/02 (2006.01) ,A61P 37/04 (2006.01) ,A61P 37/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
075
Ethers or acetals
085
having an ether linkage to aromatic ring nuclear carbon
09
having two or more such linkages
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
131
acyclic
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
133
having hydroxy groups, e.g. sphingosine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
04
Immunostimulants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
06
Immunosuppressants, e.g. drugs for graft rejection
Applicants:
清华大学 TSINGHUA UNIVERSITY [CN/CN]; 中国北京市 海淀区清华大学医学科学楼D301 D301, Medical Science Building Tsinghua University, Haidian District Beijing 100084, CN
Inventors:
石彦 SHI, Yan; CN
Agent:
北京纪凯知识产权代理有限公司 JEEKAI & PARTNERS; 中国北京市 丰台区广安路9号5号楼15A层 Floor 15A, Building No. 5 9 Guang'an Road, Fengtai District Beijing 100055, CN
Priority Data:
201710771705.731.08.2017CN
Title (EN) APPLICATION OF GPR18 AND REGULATOR THEREOF IN PREVENTION AND TREATMENT OF IMMUNE SYSTEM DISEASES
(FR) APPLICATION DE GPR18 ET SON RÉGULATEUR DANS LA PRÉVENTION ET LE TRAITEMENT DE MALADIES DU SYSTÈME IMMUNITAIRE
(ZH) GPR18及其调节剂在防治免疫系统疾病中的应用
Abstract:
(EN) An application of GPR18 and regulator thereof in the preparation of drugs for preventing and treating immune system diseases, comprising: preventing and/or treating immune disorder-related diseases, such as rheumatism, lupus erythematosus, enteritis, and multiple sclerosis, regulating the function of the peripheral immune system, and enhancing a body immunity function; and driving or inhibiting the transfer of intestinal-derived dendritic cells to lymph nodes, promoting or inhibiting the development of the lymph nodes, and/or promoting or inhibiting the function of lymph nodes.
(FR) L'invention concerne une application de GPR18 et son régulateur dans la préparation de médicaments pour la prévention et le traitement de maladies du système immunitaire, comprenant : la prévention et/ou le traitement de maladies liées au trouble immunitaire, tels que les rhumatismes, le lupus érythémateux, l'entérite et la sclérose en plaques, la régulation de la fonction du système immunitaire périphérique, et l'amélioration d'une fonction d'immunité corporelle; et la conduite ou l'inhibition du transfert de cellules dendritiques dérivées de l'intestin vers des ganglions lymphatiques, la promotion ou l'inhibition du développement des ganglions lymphatiques, et/ou la promotion ou l'inhibition de la fonction de ganglions lymphatiques.
(ZH) GPR18及其调节剂在制备防治免疫系统疾病的药物中的应用,包括预防和/或治疗免疫紊乱相关疾病,调节外周免疫系统功能,如风湿、红斑狼疮、肠炎、多发性硬化,并增强机体免疫功能;驱动或抑制肠道来源的树突状细胞向淋巴结转移,促进或抑制淋巴结发育,和/或促进或抑制淋巴结发挥功能。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)