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1. (WO2019041078) ASYMMETRIC SYNTHESIS AND USES OF COMPOUNDS IN DISEASE TREATMENTS
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Pub. No.: WO/2019/041078 International Application No.: PCT/CN2017/099221
Publication Date: 07.03.2019 International Filing Date: 28.08.2017
IPC:
A61K 31/56 (2006.01) ,A61P 15/12 (2006.01) ,A61P 19/10 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15
Drugs for genital or sexual disorders; Contraceptives
12
for climacteric disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
08
for bone diseases, e.g. rachitism, Paget's disease
10
for osteoporosis
Applicants:
ZHEJIANG JIACHI PHARMACEUTICAL DEVELOPMENT LTD. [CN/CN]; Room 1807 No. 459 Qige Road, Jianggan District Hangzhou, Zhejiang 310018, CN
Inventors:
XU, Wenping; CN
YANG, Jun; CN
Agent:
HANGZHOU TIANQIN INTELLECTUAL PROPERTY AGENCY CO., LTD.; Room 501, Zhu-Pin-Jin-Zuo No. 1 Jing-Zhou Road, Xihu District Hangzhou, Zhejiang 310013, CN
Priority Data:
Title (EN) ASYMMETRIC SYNTHESIS AND USES OF COMPOUNDS IN DISEASE TREATMENTS
(FR) SYNTHÈSE ASYMÉTRIQUE ET UTILISATIONS DE COMPOSÉS DANS DES TRAITEMENTS DE MALADIES
Abstract:
(EN) The present application discloses, among other things, asymmetric synthesis a diastereomeric compound of formula (I) (e.g., α-anordrin) or salt thereof. Also provided are methods and compositions for treatment of estrogen deficiency as well as preventing or reducing an estrogen deficiency symptom using a diastereomeric compound of formula (I) (e.g., α-anordrin) or salt thereof alone or in combination with at least one additional agent. Further provided are methods and compositions for reducing a side effect of an additional agent in the context of combination therapy with a diastereomeric compound of formula (I) (e.g., α-anordrin) or salt thereof.
(FR) La présente invention concerne, entre autres, la synthèse asymétrique d'un composé diastéréo-isomère de formule (I) (par exemple, l'α-anordrine) ou d'un sel de celui-ci. L'invention concerne également des méthodes et des compositions pour le traitement d'une carence en œstrogènes ainsi que la prévention ou la réduction d'un symptôme de carence en œstrogènes à l'aide d'un composé diastéréo-isomère de formule (I) (par exemple, l'α-anordrine) ou d'un sel de celui-ci, seul ou en association avec au moins un agent supplémentaire. L'invention concerne en outre des méthodes et des compositions pour la réduction d'un effet secondaire d'un agent supplémentaire dans le contexte d'une polythérapie avec un composé diastéréo-isomère de formule (I) (par exemple, l'α-anordrine) ou un sel de celui-ci.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)