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1. (WO2019041056) RECOMBINANT VACCINE AGAINST PROLIFERATIVE ENTEROPATHY IN ANIMALS
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Pub. No.: WO/2019/041056 International Application No.: PCT/CL2018/050073
Publication Date: 07.03.2019 International Filing Date: 28.08.2018
IPC:
A61K 39/02 (2006.01) ,C12N 15/70 (2006.01) ,C07K 14/195 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
70
Vectors or expression systems specially adapted for E. coli
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
Applicants:
UNIVERSIDAD DE CONCEPCIÓN [CL/CL]; Barrio Universitario s/n Edificio Empreudec Concepción, CL
Inventors:
MONTESINO SEGUI, Raquel; CL
TOLEDO ALONSO, Jorge; CL
RUIZ GARRIDO, Alvaro; CL
SANCHEZ RAMOS, Oliberto; CL
GUTIERREZ MELLA, Nicolas; CL
FARNOS VILLAR, Omar; CL
HIDALGO GAJARDO, Angela; CL
RAMOS DELGADO, Eduardo; CL
CORTEZ SAN MARTIN, Marcelo; CL
Agent:
SEPULVEDA BARRERA, Ximena; CL
Priority Data:
2196-201730.08.2017CL
Title (EN) RECOMBINANT VACCINE AGAINST PROLIFERATIVE ENTEROPATHY IN ANIMALS
(FR) VACCIN RECOMBINANT CONTRE L’ENTÉROPATHIE PROLIFÉRATIVE CHEZ DES ANIMAUX
(ES) VACUNA RECOMBINANTE CONTRA LA ENTEROPATÍA PROLIFERATIVA EN ANIMALES
Abstract:
(EN) The present invention relates to a recombinant vaccine against Lawsonia intracellularis, based on a recombinant synthetic chimeric variant of membrane proteins and invasins of said bacteria. In addition, the invention discloses synthetic nucleotide sequences encoding said protein variants, recombinant proteins as such, an expression cassette of said synthetic protein antigens, a transformed cell, and a method for producing said antigens, demonstrating the antigenicity and protective potential thereof against the pathogen Lawsonia intracellularis.
(FR) La présente invention concerne un vaccin recombinant contre Lawsonia intracellularis basé sur une variante chimérique synthétique recombinante de protéines de membrane et d’invasines de ladite bactérie. En outre, ladite invention concerne des séquences nucléotidiques synthétiques qui codent pour lesdites variantes protéiques, des protéines recombinantes comme telles, une cassette d'expression desdits antigènes synthétiques protéiques, une cellule transformée, et une méthode de production desdits antigènes, démontrant leur antigénécité et potentiel protecteur face à l'agent pathogène Lawsonia intracellularis.
(ES) La presente invención provee una vacuna recombinante contra Lawsonia intracellularis basada en una variante quimérica sintética recombinante de proteínas de membrana e invasinas de dicha bacteria. Adicionalmente, la invención divulga secuencias nucleotídicas sintéticas que codifican dichas variantes proteicas, proteínas recombinantes como tales, un casete de expresión de dichos antígenos sintéticos proteicos, una célula transformada y un método para la producción de dichos antígenos, demostrando su antigenicidad y potencial protecctivo frente al patógeno Lawsonia intracellularis.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)