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1. WO2019039439 - FUSION PROTEIN OF DCTN1 PROTEIN WITH RET PROTEIN

Publication Number WO/2019/039439
Publication Date 28.02.2019
International Application No. PCT/JP2018/030688
International Filing Date 20.08.2018
IPC
C07K 19/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
A61K 45/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 14/47 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 14/82 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
82Translation products from oncogenes
C07K 16/18 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
CPC
A61K 45/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 14/82
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
82Translation products from oncogenes
C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
C07K 16/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
32against translation products of oncogenes
Applicants
  • 大鵬薬品工業株式会社 TAIHO PHARMACEUTICAL CO., LTD. [JP]/[JP]
Inventors
  • 林 晃平 HAYASHI, Kohei
  • 石田 圭司 ISHIDA, Keiji
Agents
  • 特許業務法人三枝国際特許事務所 SAEGUSA & PARTNERS
Priority Data
2017-15879621.08.2017JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) FUSION PROTEIN OF DCTN1 PROTEIN WITH RET PROTEIN
(FR) PROTÉINE HYBRIDE DE PROTÉINE DCTN1 ET DE PROTÉINE RET
(JA) DCTN1タンパク質とRETタンパク質との融合タンパク質
Abstract
(EN) A novel polypeptide wherein a part of a DCTN1 protein is fused with a part of a RET protein; a polynucleotide encoding the polypeptide; a method for detecting the polynucleotide or the polypeptide; a method for screening a compound which inhibits the expression of the polynucleotide or the expression and/or activity of the polypeptide; and a medicinal composition which comprises as an active ingredient a compound inhibiting RET.
(FR) L'invention concerne un nouveau polypeptide dans lequel sont fusionnés une partie d'une protéine DCTN1 et une partie d'une protéine RET, un polynucléotide codant un polypeptide, un procédé de détection de polynucléotide et de polypeptide, un procédé de criblage de composé d'expression dudit polynucléotide ou d'expression dudit polypeptide, et/ou d'inhibition d'activité, et une composition pharmaceutique ayant pour principe actif un composé d'inhibition de RET.
(JA) DCTN1タンパク質の一部とRETタンパク質の一部とが融合した新規なポリペプチド、上記ポリペプチドをコードするポリヌクレオチド、上記ポリヌクレオチド又はポリペプチドの検出方法、上記ポリヌクレオチドの発現又はポリペプチドの発現及び/又は活性を抑制する化合物をスクリーニングする方法、及びRETを阻害する化合物を有効成分とする医薬組成物。
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