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1. (WO2019039438) OBSERVATION METHOD USING NON-HUMAN MAMMALIAN CEREBRAL INFARCTION MODEL, AND OBSERVATION DEVICE USING NON-HUMAN MAMMALIAN CEREBRAL INFARCTION MODEL
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/039438 International Application No.: PCT/JP2018/030683
Publication Date: 28.02.2019 International Filing Date: 20.08.2018
IPC:
A61B 10/00 (2006.01) ,A01K 67/027 (2006.01) ,A61B 5/0285 (2006.01) ,A61K 31/417 (2006.01) ,A61K 45/00 (2006.01) ,A61P 9/10 (2006.01) ,A61P 43/00 (2006.01) ,G01N 33/15 (2006.01) ,G01N 33/50 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
10
Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K
ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67
Rearing or breeding animals, not otherwise provided for; New breeds of animals
027
New breeds of vertebrates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
02
Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
026
Measuring blood flow
0285
Measuring phase velocity of blood waves
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
417
Imidazole-alkylamines, e.g. histamine, phentolamine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
15
Medicinal preparations
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants:
国立大学法人三重大学 MIE UNIVERSITY [JP/JP]; 三重県津市栗真町屋町1577 1577, Kurimamachiya-cho, Tsu-shi, Mie 5148507, JP
Inventors:
矢田 健一郎 YATA, Kenichiro; JP
冨本 秀和 TOMIMOTO, Hidekazu; JP
溝口 明 MIZOGUCHI, Akira; JP
稲垣 昌樹 INAGAKI, Masaki; JP
Agent:
小林 洋平 KOBAYASHI, Youhei; JP
Priority Data:
2017-15865621.08.2017JP
Title (EN) OBSERVATION METHOD USING NON-HUMAN MAMMALIAN CEREBRAL INFARCTION MODEL, AND OBSERVATION DEVICE USING NON-HUMAN MAMMALIAN CEREBRAL INFARCTION MODEL
(FR) PROCÉDÉ D'OBSERVATION UTILISANT UN MODÈLE D'INFARCTUS CÉRÉBRAL DE MAMMIFÈRE NON HUMAIN, ET DISPOSITIF D'OBSERVATION UTILISANT UN MODÈLE D'INFARCTUS CÉRÉBRAL DE MAMMIFÈRE NON HUMAIN
(JA) 非ヒト哺乳類の脳梗塞モデルによる観察方法及び非ヒト哺乳類の脳梗塞モデルによる観察装置
Abstract:
(EN) [Problem] To provide a method for observation by a non-human mammalian cerebral infarction model, and a device for observation by a non-human mammalian cerebral infarction model. [Solution] The problem addressed by the present invention is solved by a method for observing a non-human mammal in a state of cerebral infarction, the method comprising performing a procedure to make the brain of an anesthetized non-human mammal observable using a remote bilateral common carotid artery occlusion model for the non-human mammal, and observing, temporally/spatially and in real time, the cerebral infarction pathology from before the onset of infarction in a cerebral blood vessel until ischemia/abnormal contraction/reperfusion through use of a two-photon laser microscope.
(FR) Le problème décrit par la présente invention est de proposer un procédé d'observation utilisant un modèle d'infarctus cérébral de mammifère non humain, et un dispositif d'observation utilisant un modèle d'infarctus cérébral de mammifère non humain. La solution du problème selon la présente invention consiste en un procédé d'observation d'un mammifère non humain en état d'infarctus cérébral, le procédé comprenant la mise en œuvre d'une intervention pour rendre le cerveau d'un mammifère non humain anesthésié observable en utilisant un modèle d'occlusion bilatéral distant de l'artère carotide commune pour le mammifère non humain, et l'observation, dans le temps/dans l'espace et en temps réel, de la pathologie de l'infarctus cérébral depuis avant l'apparition d'un infarctus dans un vaisseau sanguin cérébral jusqu'à l'ischémie/une contraction anormale/la reperfusion en utilisant un microscope à balayage laser à deux photons.
(JA) 【課題】 非ヒト哺乳類の脳梗塞モデルによる観察方法及び非ヒト哺乳類の脳梗塞モデルによる観察装置等を提供すること。 【解決手段】 非ヒト哺乳類の両側総頸動脈遠隔閉塞モデルを用いて、麻酔下の非ヒト哺乳類の脳を観察できるように処置し、二光子レーザー顕微鏡によって、脳血管の梗塞発症前から虚血・異常収縮・再灌流までの脳梗塞病態を時間的・空間的にリアルタイムに観察する脳梗塞病態非ヒト哺乳類の観察方法によって解決される。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)