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1. (WO2019033248) TUD RNA SILENCING EXPRESSION OF HUMAN MIR-148A, MIR-152 AND MIR-424 AND USE THEREOF
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/033248 International Application No.: PCT/CN2017/097431
Publication Date: 21.02.2019 International Filing Date: 14.08.2017
IPC:
C12N 15/113 (2010.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Applicants:
深圳市博奥康生物科技有限公司 SHENZHEN BIOCAN TECHNOLOGIES CO., LTD [CN/CN]; 中国广东省深圳市 南山区珠光路134号珠光创新科技园1栋509毛吉炎 Jiyan MAO Room 509, Building 1, Zhuguang Innovation Park, No. 134 Zhuguang Road, Nanshan District Shenzhen, Guangdong 518055, CN
Inventors:
毛吉炎 MAO, Jiyan; CN
Priority Data:
Title (EN) TUD RNA SILENCING EXPRESSION OF HUMAN MIR-148A, MIR-152 AND MIR-424 AND USE THEREOF
(FR) ARN TUD INHIBANT L'EXPRESSION DES MIR-148A, MIR-152 ET MIR-424 HUMAINS ET SON UTILISATION
(ZH) 沉默人 miR-148a 、 miR-152 和 miR-424 表达的 Tud RNA 及其应用
Abstract:
(EN) Provided are a TuD RNA silencing the expression of human miR-148a, miR-152 and miR-424 and the use thereof. The DNA sequence encoding the TuD RNA is as shown in the following: 5'-ggcgctaggatcatcaacgttttgcactcatctcgcgacgatacaaagtcacgtactatctgtcttgaacccaaagtcacgtgatgatcttcttgaaacacaagtattctggtcacagaatacaacgttttgcactcatctcgcgggatacaaagtcacgtactatctgtcttgaacccaaagtcacgtgatgatcttcttgaaacacaagatgatcctagcgccaccttttt-3'. The use of the TuD RNA in silencing the expression of human miR-148a, miR-152 and miR-424 comprises the construction of the TuD RNA on a lentiviral vector to obtain a recombinant vector containing the TuD RNA; and the recombinant vector containing the TuD RNA is used in human cells to achieve the purpose of inhibiting human miR-148a, miR-152 and miR-424.
(FR) L'invention concerne un ARN TuD inhibant l'expression de miR-148a, miR-152 et miR-424 humain et son utilisation. La séquence d'ADN codant pour l'ARN TuD est telle que représentée ci-dessous : 5'-ggcgctaggatcatcaacgttttgcactcatctcgcgacgatacaaagtcacgtactatctgtcttgaacccaaagtcacgtgatgatcttcttgaaacacaagtattctggtcacagaatacaacgttttgcactcatctcgcgggatacaaagtcacgtactatctgtcttgaacccaaagtcacgtgatgatcttcttgaaacacaagatgatcctagcgccaccttttt-3'. L'utilisation de l'ARN TuD pour inhibier l'expression de miR-148 a, miR-152 et miR-424 humains comprend la construction de l'ARN TuD sur un vecteur lentiviral pour obtenir un vecteur recombinant contenant l'ARN TuD; et le vecteur recombinant contenant l'ARN TuD est utilisé dans des cellules humaines pour atteindre l'objectif d'inhibition de miR-148 a, miR-152 et miR-424 humains.
(ZH) 提供了一种沉默人mir-148a、miR-152和miR-424表达的Tud RNA及其应用。编码所述Tud RNA的DNA序列,如下所示:5'-ggcgctaggatcatcaacgttttgcactcatctcgcgacgatacaaagtcacgtactatctgtcttgaacccaaagtcacgtgatgatcttcttgaaacacaagtattctggtcacagaatacaacgttttgcactcatctcgcgacgatacaaagtcacgtactatctgtcttgaacccaaagtcacgtgatgatcttcttgaaacacaagatgatcctagcgccaccttttt-3'。沉默人mir-148a、mir-152和miR-424表达的Tud RNA的应用包括将Tud RNA构建于慢病毒载体上,得到含有Tud RNA的重组载体;将含有Tud RNA的重组载体作用于人源细胞,达到抑制人mir-148a、mir-152和miR-424的目的。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)