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1. (WO2019033122) TREATMENT OF LUNG DISEASES USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/033122 International Application No.: PCT/US2018/046567
Publication Date: 14.02.2019 International Filing Date: 13.08.2018
IPC:
A61K 31/495 (2006.01) ,A61P 11/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
Applicants:
UNITY BIOTECHNOLOGY, INC. [US/US]; 3280 Bayshore Boulevard Brisbane, California 94005, US
BUCK INSTITUTE FOR RESEARCH ON AGING [US/US]; 8001 Redwood Blvd. Novato, California 94945, US
Inventors:
VLAHAKIS, Nick; US
ARMSTRONG, Scott; US
DANANBERG, Jamie; US
HUDSON, Ryan; US
BEAUSOLEIL, Anne-Marie; US
DAVID, Nathaniel; US
LABERGE, Remi-Martin; US
Agent:
NG, Rudy; US
Priority Data:
15/675,17111.08.2017US
62/684,68113.06.2018US
Title (EN) TREATMENT OF LUNG DISEASES USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS
(FR) TRAITEMENT DE MALADIES PULMONAIRES À L'AIDE D'AGENTS PHARMACEUTIQUES QUI ÉLIMINENT DES CELLULES SÉNESCENTES
Abstract:
(EN) This invention is based on the discovery that many lung diseases associated with aging are mediated at least in part by cells bearing a senescent phenotype. Senescent cells accumulate with age, and express factors that contribute to the pathophysiology of age related conditions. The severity of age-related conditions typically correlates with the abundance of senescent cells: thus, clearing senescent cells can help abrogate the condition: providing symptomatic relief, and potentially inhibiting disease progression. In accordance with this invention, a family of Bcl protein inhibitors has been developed for the treatment of lung diseases. These senolytic agents have an appropriate dose and specificity profile to be effective in the clinical management of previously intractable pulmonary diseases.
(FR) La présente invention est basée sur la découverte selon laquelle de nombreuses maladies pulmonaires associées au vieillissement sont à médiation au moins en partie par des cellules portant un phénotype sénescent. Des cellules sénescentes s'accumulent avec l'âge et expriment des facteurs qui contribuent à la pathophysiologie d'affections liées à l'âge. La gravité des affections liées à l'âge est typiquement en corrélation avec l'abondance de cellules sénescentes : ainsi, l'élimination de cellules sénescentes peut aider à éliminer l'affection, soulager des symptômes, et potentiellement inhiber la progression de la maladie. Selon la présente invention, une famille d'inhibiteurs des protéines Bcl a été développée pour le traitement de maladies pulmonaires. Ces agents senolytiques ont un profil de dose et de spécificité approprié pour être efficaces dans la gestion clinique de maladies pulmonaires antérieurement réfractaires.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)