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1. (WO2019033099) ANTI-NEURODEGENERATIVE THERAPEUTIC, METHOD OF MANUFACTURE, AND USE
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/033099 International Application No.: PCT/US2018/046491
Publication Date: 14.02.2019 International Filing Date: 13.08.2018
IPC:
A61K 38/08 (2006.01) ,A61K 38/04 (2006.01) ,C07K 7/06 (2006.01) ,C07K 7/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08
Peptides having 5 to 11 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
06
having 5 to 11 amino acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
Applicants:
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION [US/US]; 311 Main Bld. Lexington, Kentucky 40506, US
Inventors:
BRADLEY, Luke H.; US
GASH, Don M.; US
GERHARDT, Greg A.; US
Agent:
NEALEY, Tara A.; US
BISSEN, Shirley T.; US
Priority Data:
62/544,04611.08.2017US
Title (EN) ANTI-NEURODEGENERATIVE THERAPEUTIC, METHOD OF MANUFACTURE, AND USE
(FR) COMPOSÉ THÉRAPEUTIQUE ANTI-NEURODÉNÉRESCENCE, PROCÉDÉ DE FABRICATION ET UTILISATION
Abstract:
(EN) Therapeutic peptides of the following sequence are disclosed: Xaa1 - Xaa2 - Xaa3 - Xaa4 - Xaa5, and optionally further comprising Xaa6, wherein Xaa represents an amino acid; Xaa3 is proline; and subscripts represent the positions of each amino acid in the peptide sequence starting from the amino terminus of said peptide extending to the C-terminus. A therapeutic peptide optionally includes a linker that cyclizes the peptide. Also described are methods of treating a neurodegenerative disorder and/or injury in a human subject in need of such treatment by administering to the subject a therapeutically effective amount of a therapeutic peptide as disclosed herein.
(FR) L'invention concerne des peptides thérapeutiques répondant à la séquence suivante : Xaa1 - Xaa2 - Xaa3 - Xaa4 - Xaa5 et comprenant en outre éventuellement Xaa6, dans laquelle Xaa représente un acide aminé, Xaa3 représente la proline et les indices représentent les positions de chaque acide aminé dans la séquence peptique de l'extrémité amino-terminale dudit peptide jusqu'à l'extrémité C-terminale. Un peptide thérapeutique comprend éventuellement un lieur qui cyclise le peptide. L'invention concerne également des procédés de traitement d'un trouble neurodégénératif et/ou d'une lésion chez un sujet humain nécessitant un tel traitement par administration au sujet d'une quantité thérapeutiquement efficace d'un peptide thérapeutique de l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)