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1. (WO2019033007) STAPHYLOCOCCUS PSEUDINTERMEDIUS VIRULENCE FACTOR COMPOSITIONS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/033007 International Application No.: PCT/US2018/046281
Publication Date: 14.02.2019 International Filing Date: 10.08.2018
IPC:
A61K 39/085 (2006.01) ,A61K 39/39 (2006.01) ,C07K 14/31 (2006.01) ,A61K 39/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
085
Staphylococcus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
39
characterised by the immunostimulating additives, e.g. chemical adjuvants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
305
from Micrococcaceae (F)
31
from Staphylococcus (G)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
Applicants:
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION [US/US]; 600 Henley Street, 211 Conference Center Knoxville, TN 37996, US
Inventors:
KANIA, Stephen, A.; US
BEMIS, David; US
ABOUELKHAIR, Mohamed, A.; US
Agent:
TORRE, Patrick M.; US
GRAVES, Trevor, T.; US
HARGIS, Michael, S.; US
TORRE, Patrick, M.; US
DORISIO, Andrew, D.; US
Priority Data:
62/543,67610.08.2017US
Title (EN) STAPHYLOCOCCUS PSEUDINTERMEDIUS VIRULENCE FACTOR COMPOSITIONS
(FR) COMPOSITIONS DE FACTEURS DE VIRULENCE DE STAPHYLOCOCCUS PSEUDINTERMEDIUS
Abstract:
(EN) A multivalent immunogenic composition is provided, including one or more recombinant proteins selected from the group consisting of a recombinant attenuated Staphylococcus pseudintermedius Protein A (SEQ ID NO:2), a recombinant attenuated Staphylococcus pseudintermedius Leukotoxin S (SEQ ID NO:4), a recombinant attenuated Staphylococcus pseudintermedius Nucleotidase adenosine synthase protein (AdsA) (SEQ ID NO:6), a recombinant attenuated Staphylococcus pseudintermedius coagulase (SEQ ID NO:8), a recombinant attenuated Staphylococcus pseudintermedius Leukotoxin F (SEQ ID NO: 10), and a recombinant attenuated Staphylococcus pseudintermedius exotoxin 15 (SEQ ID NO: 12). Synthetic genes expressing the attenuated recombinant proteins and optimized for expression in E. coli are provided. Vaccines and therapeutic compositions comprising the one or more recombinant proteins are provided.
(FR) L'invention concerne une composition immunogène multivalente, comprenant une ou plusieurs protéines recombinées choisies dans le groupe constitué par une protéine A de Staphylococcus pseudintermedius recombinée atténuée (SEQ ID NO:2), une leucotoxine S de Staphylococcus pseudintermedius recombinée atténuée (SEQ ID NO : 4), une protéine nucléotidase adénosine synthase (AdsA) de Staphylococcus pseudintermedius recombinée atténuée (SEQ ID NO : 6), une coagulase de Staphylococcus pseudintermedius recombinée atténuée (SEQ ID NO:8), une leucotoxine F de Staphylococcus pseudintermedius recombinée atténuée (SEQ ID NO : 10), et une exotoxine 15 de Staphylococcus pseudintermedius recombinée atténuée (SEQ ID NO:12). L'invention concerne également des gènes synthétiques exprimant les protéines recombinées atténuées et optimisés pour l'expression dans E coli. L'invention concerne également des vaccins et des compositions thérapeutiques comprenant la ou les protéines recombinées.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)