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1. (WO2019032955) ENGINEERED TRANSFERRIN RECEPTOR BINDING POLYPEPTIDES
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Pub. No.: WO/2019/032955 International Application No.: PCT/US2018/046199
Publication Date: 14.02.2019 International Filing Date: 10.08.2018
IPC:
C07K 14/79 (2006.01) ,C07K 14/705 (2006.01) ,A61K 39/00 (2006.01) ,A61K 38/40 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
79
Transferrins, e.g. lactoferrins, ovotransferrins
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
40
Transferrins, e.g. lactoferrins, ovotransferrins
Applicants:
DENALI THERAPEUTICS INC. [US/US]; 151 Oyster Point Blvd., 2nd Floor South San Francisco, California 94080, US
Inventors:
CHEN, Xiaocheng; US
DENNIS, Mark S.; US
KARIOLIS, Mihalis; US
SILVERMAN, Adam P.; US
SRIVASTAVA, Ankita; US
WATTS, Ryan J.; US
WELLS, Robert C.; US
ZUCHERO, Joy Yu; US
Agent:
HAO, Joe C.; US
Priority Data:
62/543,65810.08.2017US
62/583,31408.11.2017US
PCT/US2018/01837115.02.2018US
Title (EN) ENGINEERED TRANSFERRIN RECEPTOR BINDING POLYPEPTIDES
(FR) POLYPEPTIDES DE LIAISON AU RÉCEPTEUR DE TRANSFERRINE MODIFIÉS
Abstract:
(EN) Provided herein are polypeptides that bind to a transferrin receptor, Fc dimers and fusion proteins comprising such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.
(FR) L'invention concerne des polypeptides qui se lient à un récepteur de transferrine, des dimères Fc et des protéines de fusion comprenant de tels polypeptides, et des procédés d'utilisation des polypeptides pour cibler une composition sur une cellule exprimant un récepteur de transferrine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)