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1. (WO2019032952) TRUNCATED GUINEA PIG L-ASPARAGINASE VARIANTS AND METHODS OF USE
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/032952 International Application No.: PCT/US2018/046196
Publication Date: 14.02.2019 International Filing Date: 10.08.2018
IPC:
A61K 38/17 (2006.01) ,C12N 9/82 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
78
acting on carbon to nitrogen bonds other than peptide bonds (3.5)
80
acting on amide bonds in linear amides
82
Asparaginase
Applicants:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS [US/US]; 352 Henry Administration Building 506 South Wright Street Urbana, IL 61801, US
Inventors:
LAVIE, Arnon; US
NGUYEN, Hien-Anh; US
SCHALK, Amanda; US
Agent:
LICATA, Jane, Massey; US
LICATA, Jane, Massey; US
Priority Data:
62/544,39611.08.2017US
62/544,41111.08.2017US
Title (EN) TRUNCATED GUINEA PIG L-ASPARAGINASE VARIANTS AND METHODS OF USE
(FR) VARIANTES TRONQUÉES DE LA L-ASPARAGINASE DE COCHON D'INDE ET PROCÉDÉS D'UTILISATION
Abstract:
(EN) Variant guinea pig L-asparaginases which are truncated and humanized are described as are fusion proteins containing the L-asparaginase and use of the L- asparaginases in the treatment of cancers such as acute lymphoblastic leukemia and acute myeloid leukemia.
(FR) La présente invention concerne des variants de L-asparaginases de cochon d'inde qui sont tronquées et humanisées ainsi que des protéines de fusion contenant la L-asparaginase et l'utilisation des L-asparaginases dans le traitement de cancers, comme la leucémie aiguë lymphoblastique et la leucémie aiguë myéloïde.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)