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1. (WO2019032918) STRUCTURAL PREDICTION OF PROTEINS



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2018/046139 095515-0094
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
09 August 2018 09 August 2017
Applicant
HUMAN LONGEVITY, INC.
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No.     16    
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     G06F 19/16 (2011.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     G06F
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, BIOSIS, Sequence Search, EMBASE, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
EP 2085905 A1 (IN SILICO SCIENCES INC [JP]) 05 August 2009 (2009-08-05)
1-121
the whole document
(2)
X
WO 2005057486 A2 (XENCOR INC [US]; DESJARLAIS JOHN R [US]) 23 June 2005 (2005-06-23)
1-121
see whole doc., esp. claims and examples
(3)
X
WO 2004063963 A2 (XENCOR INC [US]; CHIRINO ARTHUR J [US]; DAHIYAT BASSIL I [US]; DESJARL) 29 July 2004 (2004-07-29)
1-121
see whole doc. esp. claims and examples
(4)
X
AMIT R MAJITHIA ET AL, "Prospective functional classification of all possible missense variants in PPARG", NATURE GENETICS.,Vol. 48, No. 12, 01 December 2016 (2016-12-01), page 1570-1575,
XP055523233
1-121
cited in the application
see whole doc. esp. Figures 4 and 5,
(5)
X
US 2017152570 A1 (SOWADSKI JANUSZ [US] ET AL) 01 June 2017 (2017-06-01)
1-121
see whole doc. esp. claim 26 ff. and Figures
(6)
X
WO 0135316 A2 (STRUCTURAL BIOINFORMATICS INC [US]; QUEST DIAGNOSTICS INVEST INC [US];) 17 May 2001 (2001-05-17)
1-121
see whole doc. esp. claims
(7)
A
HUSTON J S ET AL, "PROTEIN ENGINEERING OF ANTIBODY BINDING SITES: RECOVERY OF SPECIFIC ACTIVITY IN AN ANTI-DIGOXIN SINGLE-CHAIN FV ANALOGUE PRODUCED IN ESCHERICHIA COLI", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATIONAL ACADEMY OF SCIENCES, US,Vol. 85, No. 16, 01 August 1988 (1988-08-01), page 5879-5883,
XP000872837
1-121
the whole document
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
EP 2085905 A1
05 August 2009
EP 2085905 A1
JP 4643713 B2
JP WO2008062906 A1
US 2010057420 A1
WO 2008062906 A1
05 August 2009
02 March 2011
04 March 2010
04 March 2010
29 May 2008
WO 2005057486 A2
23 June 2005
AU 2004298058 A1
CA 2548482 A1
EP 1695252 A2
WO 2005057486 A2
23 June 2005
23 June 2005
30 August 2006
23 June 2005
WO 2004063963 A2
29 July 2004
AU 2004204942 A1
CA 2512693 A1
EP 1581904 A2
US 2004230380 A1
WO 2004063963 A2
29 July 2004
29 July 2004
05 October 2005
18 November 2004
29 July 2004
US 2017152570 A1
01 June 2017
NONE
WO 0135316 A2
17 May 2001
AU 1760001 A
EP 1228370 A2
US 2003158672 A1
US 2005004766 A1
US 2006217894 A1
US 2012010866 A1
WO 0135316 A2
06 June 2001
07 August 2002
21 August 2003
06 January 2005
28 September 2006
12 January 2012
17 May 2001
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
14 November 2018
Date of mailing of the international search report:
21 November 2018
Authorized officer:
Mueller, Frank
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