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1. (WO2019032836) IMMUNODEFICIENT MICE EXPRESSING HUMAN INTERLEUKIN 15
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Pub. No.: WO/2019/032836 International Application No.: PCT/US2018/046021
Publication Date: 14.02.2019 International Filing Date: 09.08.2018
IPC:
A01K 67/027 (2006.01) ,C07K 14/54 (2006.01) ,C12N 5/078 (2010.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K
ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67
Rearing or breeding animals, not otherwise provided for; New breeds of animals
027
New breeds of vertebrates
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
54
Interleukins (IL)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
Applicants:
THE JACKSON LABORATORY [US/US]; 600 Main Street Bar Harbor, ME 04609, US
UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL [US/US]; 373 Plantation Street Biotech 2, Suite 218 Worcester, MA 01604, US
Inventors:
SHULTZ, Leonard, D.; US
BREHM, Michael, A.; US
GREINER, Dale, L.; US
Agent:
DIPIETRANTONIO, Heather, J.; US
MCEVOY, Douglas, J.; US
GOULD, Westton, R.; US
ANDERSON, Thomas, E.; US
MACKENZIE, Kevin, S.; US
Priority Data:
62/543,21809.08.2017US
62/554,81806.09.2017US
Title (EN) IMMUNODEFICIENT MICE EXPRESSING HUMAN INTERLEUKIN 15
(FR) SOURIS IMMUNODÉFICIENTES EXPRIMANT L'INTERLEUKINE 15 HUMAINE
Abstract:
(EN) An immunodeficient mouse is provided which is useful as a model of functions and regulation of human natural killer (NK) cells and other interleukin 15 (IL-15)-dependent cell populations and processes in studies of human immunity, cancer, infectious diseases, and other areas. According to specific aspects, an immunodeficient mouse is provided which is genetically modified to express human interleukin 15, wherein the mouse does not have or produce functional mouse natural killer cells, and wherein the mouse is modified to include human natural killer cells. Methods of identifying anti-tumor activity of a test substance using a mouse of the present invention are described along with methods of making the mouse.
(FR) L'invention concerne une souris immunodéficiente qui est utile en tant que modèle de fonctions et de régulation des cellules tueuses naturelles (NK) humaines et d'autres populations de cellules dépendantes de l'interleukine 15 (IL-15) et des processus dans des études de l'immunité humaine, du cancer, de maladies infectieuses et d'autres domaines. Selon certains aspects spécifiques, l'invention concerne une souris immunodéficiente qui est génétiquement modifiée pour exprimer l'interleukine 15 humaine, la souris n'ayant pas ou ne produisant pas de cellules tueuses naturelles de souris fonctionnelles, et la souris étant modifiée pour comprendre des cellules tueuses naturelles humaines. L'invention concerne également des procédés d'identification d'une activité antitumorale d'une substance d'essai à l'aide d'une souris de la présente invention ainsi que des procédés de production de ladite souris.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)