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1. (WO2019032743) COMPOUNDS, COMPOSITIONS AND METHODS
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/032743 International Application No.: PCT/US2018/045868
Publication Date: 14.02.2019 International Filing Date: 08.08.2018
IPC:
C07C 211/38 (2006.01) ,C07C 217/52 (2006.01) ,C07C 233/05 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
211
Compounds containing amino groups bound to a carbon skeleton
33
having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
34
of a saturated carbon skeleton
38
containing condensed ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
217
Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
52
having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
01
having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
02
having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
04
with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic saturated carbon skeleton
05
having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
Applicants:
DENALI THERAPEUTICS INC. [US/US]; 151 Oyster Point Blvd., 2nd Floor South San Francisco, California 94080, US
Inventors:
CRAIG, Robert A., II; US
ESTRADA, Anthony A.; US
FENG, Jianwen A.; US
FOX, Brian; US
HALE, Christopher R. H.; US
LEXA, Katrina W.; US
OSIPOV, Maksim; US
REMARCHUK, Travis; US
SWEENEY, Zachary K.; US
DE VICENTE FIDALGO, Javier; US
Agent:
TANNER, Lorna L.; US
HIRAYAMA, Lacie C.; US
HUANG, Wenrong; US
NEMIROW, Joy L.; US
NIE, Alex Y.; US
THAKUR, Neeta C.; US
Priority Data:
62/543,30709.08.2017US
62/553,72801.09.2017US
62/608,50420.12.2017US
Title (EN) COMPOUNDS, COMPOSITIONS AND METHODS
(FR) COMPOSÉS, COMPOSITIONS ET PROCÉDÉS
Abstract:
(EN) The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.
(FR) La présente invention concerne d'une manière générale des modulateurs du facteur 2B d'initiation eucaryote, ou un sel, un stéréoisomère, un mélange de stéréoisomères ou un promédicament pharmaceutiquement acceptable de ceux-ci, et des procédés de fabrication et d'utilisation de ceux-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)