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1. (WO2019032609) SYSTEMS AND METHODS FOR SEPARATING CANNABIS-DERIVED COMPOUNDS USING CHROMATOGRAPHY WITH LIQUID OR SUPERCRITICAL CARBON DIOXIDE
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/032609 International Application No.: PCT/US2018/045656
Publication Date: 14.02.2019 International Filing Date: 07.08.2018
IPC:
B01D 15/40 (2006.01) ,C07D 311/80 (2006.01) ,A61K 31/352 (2006.01) ,C07D 401/12 (2006.01)
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
D
SEPARATION
15
Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08
Selective adsorption, e.g. chromatography
26
characterised by the separation mechanism
40
using supercritical fluid as mobile phase or eluent
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
311
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02
ortho- or peri-condensed with carbocyclic rings or ring systems
78
Ring systems having three or more relevant rings
80
Dibenzopyrans; Hydrogenated dibenzopyrans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Avenue Cambridge, MA 02139, US
Inventors:
COLTON, Clark, K.; US
MOSES, John, M.; US
WILSON, Veronica, M.; US
DALZELL, William, H.; US
LAYUROVA, Mariya; US
ELIAN, Tony, J.; US
CAI, Truong, H.; US
MACKAY, John; US
Agent:
NYEIN, Michelle, K.; US
Priority Data:
62/542,23907.08.2017US
62/542,24807.08.2017US
Title (EN) SYSTEMS AND METHODS FOR SEPARATING CANNABIS-DERIVED COMPOUNDS USING CHROMATOGRAPHY WITH LIQUID OR SUPERCRITICAL CARBON DIOXIDE
(FR) SYSTÈMES ET PROCÉDÉS DE SÉPARATION DE COMPOSÉS DÉRIVÉS DU CANNABIS PAR CHROMATOGRAPHIE AVEC DU DIOXYDE DE CARBONE LIQUIDE OU SUPERCRITIQUE
Abstract:
(EN) Chromatography systems and methods for using carbon dioxide to separate one or more cannabis-derived compounds from other components of a mixture are generally described. Some of the methods described herein comprise transporting a mixture comprising a first cannabis-derived compound and one or more other components through a chromatography column containing a stationary phase comprising a packing material. In some embodiments, the mixture is transported through the column within a mobile phase that comprises carbon dioxide (e.g., supercritical CO2, liquid CO2). The mobile phase may be substantially free of a co-solvent that is in liquid phase at standard room temperature and pressure. In some embodiments, the mobile phase is free of any co-solvent and comprises 100 vol% carbon dioxide. The first cannabis- derived compound may interact with the stationary phase and/or the mobile phase to a different degree than the one or more other components of the mixture, causing at least partial separation of the first cannabis-derived compound from the one or more other components within the column. Due to this separation, at least one fraction of the mobile phase that comprises the first cannabis-derived compound and is substantially free of the one or more other components of the mixture may be collected.
(FR) L'invention concerne de manière générale des systèmes de chromatographie et des procédés d'utilisation de dioxyde de carbone pour séparer un ou plusieurs composés dérivés du cannabis provenant d'autres composants d'un mélange. Certains des procédés décrits ici comprennent le transport d'un mélange comprenant un premier composé dérivé du cannabis et un ou plusieurs autres composants par l'intermédiaire d'une colonne de chromatographie contenant une phase stationnaire comprenant un matériau d'emballage. Dans certains modes de réalisation, le mélange est transporté à travers la colonne à l'intérieur d'une phase mobile qui comprend du dioxyde de carbone (par exemple, CO2 supercritique, CO2 liquide). La phase mobile peut être sensiblement exempte d'un cosolvant qui est en phase liquide à température et pression ambiantes standard. Dans certains modes de réalisation, la phase mobile est exempte de tout cosolvant et comprend 100 % en volume de dioxyde de carbone. Le premier composé dérivé du cannabis peut interagir avec la phase stationnaire ou la phase mobile à un degré différent du ou des autres composants du mélange, ce qui provoque une séparation au moins partielle du premier composé dérivé du cannabis à partir du ou des autres composants à l'intérieur de la colonne. Du fait de cette séparation, au moins une fraction de la phase mobile comprenant le premier composé dérivé du cannabis et qui est sensiblement exempte du ou des autres composants du mélange peut être collectée.
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African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)