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1. (WO2019032547) MACROCYCLIC IMMUNOMODULATORS
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/032547 International Application No.: PCT/US2018/045553
Publication Date: 14.02.2019 International Filing Date: 07.08.2018
IPC:
A61K 31/195 (2006.01) ,A61K 31/335 (2006.01) ,C07C 15/24 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
15
Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic part
20
Polycyclic condensed hydrocarbons
24
containing two rings
Applicants:
CHEMOCENTRYX, INC. [US/US]; 850 Maude Avenue Mountain View, CA 94043, US
Inventors:
MALATHONG, Viengkham; US
MCMAHON, Jeffrey; US
MCMURTRIE, Darren, J.; US
PUNNA, Sreenivas; US
ROTH, Howard, S.; US
SINGH, Rajinder; US
ZHANG, Penglie; US
Agent:
KEZER, William, B.; US
TRIMBLE, Alexander, R.; US
DOLAN, Gregory, F.; US
Priority Data:
62/542,69408.08.2017US
Title (EN) MACROCYCLIC IMMUNOMODULATORS
(FR) IMMUNOMODULATEURS MACROCYCLIQUES
Abstract:
(EN) Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I) or (II) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R, R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, R6c, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
(FR) L'invention concerne des composés qui sont utiles en tant qu'immunomodulateurs. Les composés ont la formule suivante (I) ou (II) comprenant des stéréoisomères et des sels pharmaceutiquement acceptables de ceux-ci, dans laquelle R, R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, R6c, m et n sont tels que définis dans la description. L'invention concerne également, des procédés associés à l'élaboration et à l'utilisation de tels composés, et des compositions pharmaceutiques comprenant de tels composés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)