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1. (WO2019032525) METHODS FOR SUBTYPING OF HEAD AND NECK SQUAMOUS CELL CARCINOMA
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/032525 International Application No.: PCT/US2018/045522
Publication Date: 14.02.2019 International Filing Date: 07.08.2018
IPC:
C07K 16/28 (2006.01) ,C12Q 1/6853 (2018.01) ,C40B 40/08 (2006.01) ,G01N 33/574 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
[IPC code unknown for C12Q 1/6853]
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40
Libraries per se, e.g. arrays, mixtures
04
Libraries containing only organic compounds
06
Libraries containing nucleotides or polynucleotides, or derivatives thereof
08
Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants:
GENECENTRIC THERAPEUTICS, INC. [US/US]; 79 TW Alexander Drive 4401 Research Commons, Suite 105 Research Triangle Park, North Carolina 27709, US
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL [US/US]; 109 Church Street Chapel Hill, North Carolina 27516, US
Inventors:
LAI-GOLDMAN, Myla; US
FARUKI, Hawazin; US
MAYHEW, Greg; US
PEROU, Charles; US
HAYES, David Neil; US
Agent:
MCEVOY, Michael T.; US
TUSCAN, Michael S.; US
WHITTLE, James R.R.; US
Priority Data:
62/541,96007.08.2017US
62/608,21820.12.2017US
62/629,93413.02.2018US
Title (EN) METHODS FOR SUBTYPING OF HEAD AND NECK SQUAMOUS CELL CARCINOMA
(FR) PROCÉDÉ DE SOUS-TYPAGE D'UN CARCINOME ÉPIDERMOÏDE DE LA TÊTE ET DU COU
Abstract:
(EN) Methods and compositions are provided for determining a subtype of head and neck squamous cell carcinoma (HNSCC) of an individual by detecting the expression level of at least one classifier biomarker selected from a group of gene signatures for HNSCC. Also provided herein are methods and compositions for determining the response of an individual with a HNSCC subtype to a therapy such as immunotherapy.
(FR) L'invention concerne des procédés et des compositions permettant de déterminer un sous-type de carcinome épidermoïde de la tête et du cou d'un individu par détection du niveau d'expression d'au moins un biomarqueur de classification choisi dans un groupe de signatures géniques pour le carcinome épidermoïde de la tête et du cou. L'invention concerne également des procédés et des compositions permettant de déterminer la réponse d'un individu ayant un sous-type de carcinome épidermoïde de la tête et du cou à une thérapie telle qu'une immunothérapie.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)