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1. (WO2019032463) IMMUNOGINIC COMPOSITIONS COMPRISING CHIMERIC INFLUENZA VIRUS HEMAGGLUTININ POLYPEPTIDES AND AS01 AND USES THEREOF
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/032463 International Application No.: PCT/US2018/045399
Publication Date: 14.02.2019 International Filing Date: 06.08.2018
IPC:
A61K 39/12 (2006.01) ,A61K 39/145 (2006.01) ,C07K 14/005 (2006.01) ,C12N 7/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
145
Orthomyxoviridae, e.g. influenza virus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
01
DNA viruses
03
Herpetoviridae, e.g. pseudorabies virus
05
Epstein-Barr virus
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7
Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
Applicants:
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI [US/US]; One Gustave L. Levy Place Box 1675 New York, NY 10029, US
GLAXOSMITHLINE BIOLOGICALS S.A. [BE/BE]; Rue de l'institut 89 B-1330 Rixensart, BE
Inventors:
PALESE, Peter; US
KRAMMER, Florian; US
GARCIA-SASTRE, Adolfo; US
NACHBAGAUER, Raffael; US
MALLETT, Corey, Patrick; US
INNIS, Bruce; US
HANON, Emmanuel, Jules; US
Agent:
CHHEDA, Jennifer, J.; US
ANTLER, Adriane, M.; US
PAULSON, Mark; US
MCNICHOLAS, Janet, M.; US
NIX, Kelsey; US
Priority Data:
62/542,14307.08.2017US
Title (EN) IMMUNOGINIC COMPOSITIONS COMPRISING CHIMERIC INFLUENZA VIRUS HEMAGGLUTININ POLYPEPTIDES AND AS01 AND USES THEREOF
(FR) COMPOSITIONS IMMUNOGÈNES COMPRENANT DES POLYPEPTIDES CHIMÈRES D'HÉMAGGLUTININE DU VIRUS DE LA GRIPPE ET AS01 ET LEURS UTILISATIONS
Abstract:
(EN) Provided herein are immunization regimens for inducing an immune response (e.g., an antibody response) against influenza virus. In specific aspects, the immunization regimens involve the administration of a chimeric hemagglutinin (HA) and a liposomal adjuvant (e.g., ASOl) to a subject. Also provided herein are immunogenic/vaccine compositions for use in methods of immunizing or immunization regimens for human subjects against influenza virus.
(FR) La présente invention concerne des programmes d'immunisation permettant d'induire une réponse immunitaire (par exemple, une réponse d'anticorps) contre le virus de la grippe. Dans des aspects spécifiques, les programmes d'immunisation impliquent l'administration d'une hémagglutinine chimère (HA) et d'un adjuvant liposomal (par exemple, ASOl) à un sujet. L'invention concerne également des compositions immunogènes/vaccinales destinées à être utilisées dans des méthodes d'immunisation ou dans des programmes d'immunisation pour des sujets humains contre le virus de la grippe.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)