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1. (WO2019032411) COMPOSITIONS AND METHODS FOR INDUCING APOPTOSIS IN ANAEROBIC CELLS AND RELATED CLINICAL METHODS FOR TREATING CANCER AND PATHOGENIC INFECTIONS
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/032411 International Application No.: PCT/US2018/045301
Publication Date: 14.02.2019 International Filing Date: 05.08.2018
IPC:
C07H 19/24 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
24
Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
Applicants:
COGNATE 3 LLC [US/US]; 218 Main Street - Suite 287 Kirkland, WA 98033, US
BROWN, Joe Ernest [US/US]; US
ROBERTS, Suzannah Jane [US/US]; US
Inventors:
BROWN, Joe Ernest; US
ROBERTS, Suzannah Jane; US
Agent:
KING, Jeffrey, J.; US
Priority Data:
62/605,35207.08.2017US
Title (EN) COMPOSITIONS AND METHODS FOR INDUCING APOPTOSIS IN ANAEROBIC CELLS AND RELATED CLINICAL METHODS FOR TREATING CANCER AND PATHOGENIC INFECTIONS
(FR) COMPOSITIONS ET PROCÉDÉS PERMETTANT D'INDUIRE L'APOPTOSE DANS DES CELLULES ANAÉROBIES ET PROCÉDÉS CLINIQUES ASSOCIÉS POUR LE TRAITEMENT DU CANCER ET D'INFECTIONS PATHOGÈNES
Abstract:
(EN) The invention provides potent anti-cancer methods and compositions that employ novel glycome compounds exemplified by glyco-benzaldehydes that disrupt anaerobic respiration and trigger apoptosis in cancer cells. Additionally, the invention provides useful compositions and methods to treat viral and microbial infections, and for enhancing suppressed immune systems, including by disrupting alpha-N-acetylgalactosaminidase (nagalase) function and lov/ering circulating nagalase blood levels. In certain anti-cancer and immune enhancing methods and compositions of the invention glyco-benzaldehyde compounds, such as the plant-deri ved glyco- benzaldehyde helicidum, are employed, alone or in combination, to potently destroy tumors and c irculating cancer cells, and significantly prolong survival of cancer patients, including treatment-resistant Stage III and Stage IV cancer patients.
(FR) L'invention concerne de puissants procédés anticancéreux ainsi que des compositions anticancéreuses utilisant de nouveaux composés de glycome illustrés par des glyco-benzaldéhydes qui perturbent la respiration anaérobie et déclenchent l'apoptose dans des cellules cancéreuses. L'invention concerne également des compositions et des procédés utiles pour traiter des infections virales et microbiennes, et pour renforcer des systèmes immunitaires affaiblis, notamment en perturbant la fonction alpha-N-acétylgalactosaminidase (nagalase) et en diminuant les taux de nagalase en circulation dans le sang. Selon certains procédés et compositions fournis par la présente invention et destinés à un traitement anticancéreux et à l'amélioration immunitaire, on utilise des composés glyco-benzaldéhydes, tels que le glyco-benzaldéhyde d'hélicidum dérivé de plantes, seul ou en association, pour détruire puissamment des tumeurs et des cellules cancéreuses en circulation, et pour prolonger de manière significative la survie de patients atteints d'un cancer, notamment des patients atteints d'un cancer de stade III et de stade IV résistant au traitement.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)