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1. (WO2019032057) METHOD FOR PREPARING NANO-PARTICLE OF TILMICOSIN AND PRODUCT THEREOF
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Pub. No.: WO/2019/032057 International Application No.: PCT/TH2017/000061
Publication Date: 14.02.2019 International Filing Date: 11.08.2017
IPC:
A61K 9/14 (2006.01) ,A61K 47/14 (2006.01) ,A61K 47/44 (2006.01) ,A61K 31/7048 (2006.01) ,A61K 31/706 (2006.01) ,B82Y 5/00 (2011.01) ,B82Y 40/00 (2011.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
14
Esters of carboxylic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
44
Oils, fats or waxes according to more than one of groups A61K47/02-A61K47/42109
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7048
having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706
containing six-membered rings with nitrogen as a ring hetero atom
B PERFORMING OPERATIONS; TRANSPORTING
82
NANO-TECHNOLOGY
Y
SPECIFIC USES OR APPLICATIONS OF NANO-STRUCTURES; MEASUREMENT OR ANALYSIS OF NANO-STRUCTURES; MANUFACTURE  OR TREATMENT OF NANO-STRUCTURES
5
Nano-biotechnology or nano-medicine, e.g. protein engineering or drug delivery
B PERFORMING OPERATIONS; TRANSPORTING
82
NANO-TECHNOLOGY
Y
SPECIFIC USES OR APPLICATIONS OF NANO-STRUCTURES; MEASUREMENT OR ANALYSIS OF NANO-STRUCTURES; MANUFACTURE  OR TREATMENT OF NANO-STRUCTURES
40
Manufacture or treatment of nano-structures
Applicants:
VET PRODUCTS RESEARCH AND INNOVATION CENTER COMPANY LIMITED [TH/TH]; 141 Thailand Science Park, Innovation Cluster 2 Building, 11th floor, Room No. INC 2D-1109 - INC 2D-1111 Phahonyothin Road, Khlong Nueng, Klong Luang, Pathumthani 12120, TH
Inventors:
SURASSMO, Suvimol; TH
YOSTAWONKUL, Jakrawan; TH
NAMDEE, Katawut; TH
RUKTANONCHAI, Uracha; TH
SAENGKRIT, Nattika; TH
YATA, Teerapong; TH
RUENNARONG, Nitwarat; TH
KHONKHAYAN, Pattapong; TH
NUNTA, Kanokkan; TH
Agent:
ORNTHANALAI, Veravej; Intellectual Design Group Company Limited 360 Nonthaburi Road, Bangkrasor, Muang Nonthaburi, 11000, TH
Priority Data:
Title (EN) METHOD FOR PREPARING NANO-PARTICLE OF TILMICOSIN AND PRODUCT THEREOF
(FR) PROCÉDÉ DE PRÉPARATION D'UNE NANOPARTICULE DE TILMICOSINE ET D'UN PRODUIT À BASE DE CELLE-CI
Abstract:
(EN) A set of tilmicosin nanoparticles and their preparation method involves the method of synthesizing the tilmicosin nanoparticles which are used as antibiotics for controlling and treating infectious conditions or diseases in the respiratory systems of animals. The tilmicosin nanoparticles according to this invention comprises a tilmicosin antibiotic base : a surfactant : an oil : a water in the proportions of 0.3-0.6 : 3-6 : 0.5-5.5 : 88-96 % by weight wherein the derived tilmicosin exhibits superior absorption capability in the animals' digestive systems than the conventional tilmicosin medication, and is also highly stable and non-toxic to the digestive systems of animals.
(FR) Cette invention concerne un ensemble de nanoparticules de tilmicosine et leur procédé de préparation qui implique un procédé de synthèse des nanoparticules de tilmicosine qui sont utilisées comme antibiotiques pour maîtriser et traiter les affections ou les maladies infectieuses du système respiratoire chez l'animal. Les nanoparticules de tilmicosine selon la présente invention comprennent une base antibiotique de tilmicosine : un tensioactif : une huile : de l'eau, dans des proportions de 0,3-0,6 : 3-6 : 0,5-5,5 : 88-96 % en poids, où la tilmicosine dérivée manifeste une capacité d'absorption supérieure dans le système digestif animal à la tilmicosine du médicament classique, et est également très stable et non toxique pour le système digestif animal.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: Thai (TH)