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1. (WO2019031981) HEPATITIS VIRUS ENTRY INHIBITOR AND PHARMACEUTICAL COMPOSITION FOR TREATING HEPATITIS
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/031981 International Application No.: PCT/RU2018/000125
Publication Date: 14.02.2019 International Filing Date: 02.03.2018
IPC:
C07D 285/32 (2006.01) ,A61K 31/5415 (2006.01) ,A61K 31/20 (2006.01) ,A61P 1/16 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
285
Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/-C07D283/183
15
Six-membered rings
16
Thiadiazines; Hydrogenated thiadiazines
18
1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
20
condensed with carbocyclic rings or ring systems
22
condensed with one six-membered ring
24
with oxygen atoms directly attached to the ring sulfur atom
26
substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals
32
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 3
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
54
having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
5415
ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
20
having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Applicants:
ИВАЩЕНКО, Алена Александровна IVACHTCHENKO, Alena Alexandrovna [US/US]; US
АЛЛА ХЕМ, ЛЛС ALLA CHEM, LLC [US/US]; 1835 Еаст Халландале Беач Блвд 442, Халландале Беач, Флорида, 1835 East Hallandale Beach Blvd 442 Hallandale Beach, Florida 33009, US
ИВАЩЕНКО, Александр Васильевич IVACHTCHENKO, Alexandre Vasilievich [RU/RU]; RU
ИВАЩЕНКО, Андрей Александрович IVASHCHENKO, Andrey Alexandrovich [RU/RU]; RU
САВЧУК, Николай Филиппович SAVCHUK, Nikolay Filippovich [US/US]; US
Inventors:
ИВАЩЕНКО, Александр Васильевич IVACHTCHENKO, Alexandre Vasilievich; RU
ИВАЩЕНКО, Андрей Александрович IVASHCHENKO, Andrey Alexandrovich; RU
САВЧУК, Николай Филиппович SAVCHUK, Nikolay Filippovich; US
РОГОВОЙ, Борис ROGOVOJ, Boris; US
БЫЧКО, Вадим Васильевич BYCHKO, Vadim Vasilievich; US
ХВАТ, Александр KHVAT, Alexander; US
Priority Data:
201712871211.08.2017RU
Title (EN) HEPATITIS VIRUS ENTRY INHIBITOR AND PHARMACEUTICAL COMPOSITION FOR TREATING HEPATITIS
(FR) INHIBITEUR D’ENTRÉE DU VIRUS DE L'HÉPATITE ET COMPOSITION PHARMACEUTIQUE POUR TRAITER L’HÉPATITE
(RU) ИНГИБИТОР ВХОДА ВИРУСА ГЕПАТИТА И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ ДЛЯ ЛЕЧЕНИЯ ГЕПАТИТА
Abstract:
(EN) The present invention relates to novel hepatitis delta virus (HDV) entry inhibitors, to a novel pharmaceutical composition, and to a method for treating HDV infection and co-infection of HDV and hepatitis B virus (HBV). The present hepatitis delta virus entry inhibitor is 1,1-dioxo-1,4-dihydro-2H-benzo[1,2,4]thiadiazin-3-one of general formula 1, or a hydrate and/or solvate thereof, wherein Ar1 and Ar2 are optionally identical aryls, including phenyl, optionally substituted with one, two or three substituents selected from C1-C4 alkyl, methoxyl, halogen, carboxyl of optionally substituted carbamoyl and carbonitrile.
(FR) L'invention concerne de nouveaux inhibiteurs de pénétration du virus de l'hépatite Delta (VHD), une nouvelle composition pharmaceutique et une méthode de traitement de l’infection par VHD et de co-infection par VHD et par le virus de l'hépatite B (VHB). L’inhibiteur de pénétration du virus de l'hépatite Delta se présente comme 1,1-dioxo-1,4-dihydro-2N-benzo[1,2,4]tiadiazin-3-on ayant la formule générale 1, son hydrate ou son solvate dans lesquels Аr1 et Аr2 se présente comme des aryles éventuellement identiques, y compris phényle éventuellement substitué par un, deux ou trois substitutifs sélectionnés parmi alkyle C1-С4, méthoxyle, halogène, carboxyle, carbamoyle éventuellement substitué et carbonitryle.
(RU) Данное изобретение относится к новым ингибиторам входа вируса гепатита дельта (ВГД), новой фармацевтической композиции и способу лечения инфекции ВГД и ко-инфекции ВГД и вируса гепатита В (ВГВ). Ингибитор входа вируса гепатита дельта, представляющий собой 1,1-диоксо-1,4-дигидро-2Н-бензо[1,2,4]тиадиазин-3-он общей формулы 1, его гидрат и/или сольват, где Аr1 и Аr2 представляют собой необязательно одинаковые арилы, в том числе фенил, необязательно замещенный одним, двумя или тремя заместителями, выбранными из C1-С4алкила, метоксила, галогена, карбоксила необязательно замещенного карбамоила и карбонитрила.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Russian (RU)
Filing Language: Russian (RU)