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1. (WO2019030808) MICROORGANISM CAPABLE OF PRODUCING AROMATIC COMPOUND
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/030808 International Application No.: PCT/JP2017/028650
Publication Date: 14.02.2019 International Filing Date: 07.08.2017
IPC:
C12N 1/21 (2006.01) ,C12P 7/22 (2006.01) ,C12P 13/22 (2006.01) ,C12N 15/09 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
21
modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
02
containing a hydroxy group
22
aromatic
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13
Preparation of nitrogen-containing organic compounds
04
Alpha- or beta-amino acids
22
Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
Applicants:
地方独立行政法人大阪産業技術研究所 OSAKA RESEARCH INSTITUTE OF INDUSTRIAL SCIENCE AND TECHNOLOGY [JP/JP]; 大阪府和泉市あゆみ野2丁目7番1号 7-1, Ayumino 2-chome, Izumi-shi, Osaka 5941157, JP
Inventors:
駒大輔 KOMA Daisuke; --
大本貴士 OHMOTO Takashi; --
山中勇人 YAMANAKA Hayato; --
森芳邦彦 MORIYOSHI Kunihiko; --
Agent:
特許業務法人池内アンドパートナーズ IKEUCHI & PARTNERS; 大阪府大阪市北区天満橋1丁目8番30号OAPタワー26階 26th Floor, OAP TOWER, 8-30, Tenmabashi 1-chome, Kita-ku, Osaka-shi, Osaka 5306026, JP
Priority Data:
Title (EN) MICROORGANISM CAPABLE OF PRODUCING AROMATIC COMPOUND
(FR) MICRO-ORGANISME CAPABLE DE PRODUIRE UN COMPOSÉ AROMATIQUE
(JA) 芳香族化合物を産生する微生物
Abstract:
(EN) Provided is a microorganism which is plasmid-free and has improved productivity. In one aspect, the present disclosure relates to a transgenic microorganism belonging to the genus Escherichia, in which at least five genes shown below are introduced onto the chromosome thereof along with promoters respectively capable of inducing the expression of the genes: (1) aroA, (2) aroB, (3) aroC, (4) aroGfbr or aroFfbr, and (5) pheAfbr or tyrAfbr. In another aspect, the present disclosure relates to a method for producing an aromatic compound, comprising culturing the microorganism in a culture medium.
(FR) L'invention concerne un micro-organisme qui est exempt de plasmide et qui présente une productivité améliorée. Dans un aspect, la présente invention concerne un micro-organisme transgénique appartenant au genre Escherichia, dans lequel au moins cinq gènes présentés ci-dessous sont introduits sur le chromosome correspondant conjointement avec des promoteurs respectivement capables d'induire l'expression des gènes : (1) aroA, (2) aroB, (3) aroC, (4) aroGfbr ou aroFfbr et (5) pheAfbr ou tyrAfbr. Dans un autre aspect, la présente invention concerne un procédé de production d'un composé aromatique, comprenant la culture du micro-organisme dans un milieu de culture.
(JA) プラスミドフリーでかつ生産性が向上した微生物の提供。 本開示は、一態様において、形質転換されたエシェリキア属に属する微生物であって、少なくとも下記5つの遺伝子が染色体上に発現誘導可能なプロモーターとともに導入されている微生物に関する。 (1)aroA (2)aroB (3)aroC (4)aroGfbr又はaroFfbr (5)pheAfbr又はtyrAfbr 本開示は、その他の態様において、上記微生物を培地で培養することを含む、芳香族化合物の製造方法に関する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)