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1. (WO2019030311) METHOD FOR PREDICTING THE RESPONSE OF NON-SMALL-CELL LUNG CARCINOMA PATIENTS TO A MEDICAMENT
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/030311 International Application No.: PCT/EP2018/071569
Publication Date: 14.02.2019 International Filing Date: 09.08.2018
Chapter 2 Demand Filed: 28.05.2019
IPC:
C12Q 1/48 (2006.01) ,G01N 33/574 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
48
involving transferase
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants:
PAMGENE BV [NL/NL]; Wolvenhoek 10 5211 HH 's-Hertogenbosch, NL
ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM [NL/NL]; Wytemaweg 80 3015 CN Rotterdam, NL
Inventors:
RUIJTENBEEK, Robby; NL
VAN DEN HEUVEL, Dirgje, Maria, Adriana; NL
DE WIJN, Richard; NL
AERTS, Joan, Gertrudis, Jacobus, Victor; NL
MATHIJSSEN, Adrianus, Henricus, Josephus; NL
Agent:
DE CLERCQ & PARTNERS; Edgard Gevaertdreef 10a 9830 Sint-Martens-Latem, BE
Priority Data:
17185467.209.08.2017EP
Title (EN) METHOD FOR PREDICTING THE RESPONSE OF NON-SMALL-CELL LUNG CARCINOMA PATIENTS TO A MEDICAMENT
(FR) MÉTHODE DE PRÉDICTION DE LA RÉPONSE DE PATIENTS ATTEINTS D'UN CARCINOME DU POUMON NON À PETITES CELLULES À UN MÉDICAMENT
Abstract:
(EN) The present invention relates to a method for determining or predicting the response of a patient diagnosed with non-small-cell lung carcinoma to targeted pharmacotherapy. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with non-small-cell lung carcinoma to specific medicaments. More specifically, the present invention provides methods which measure kinase-activity by studying phosphorylation levels and profiles and inhibitions thereof by drugs in blood samples of said patients.
(FR) La présente invention concerne une méthode permettant de déterminer ou de prédire la réponse à une pharmacothérapie ciblée d'un patient chez qui l'on a diagnostiqué un carcinome du poumon non à petites cellules. La présente invention concerne également des méthodes et des dispositifs pour prédire la réponse à des médicaments spécifiques de patients chez qui l'on a diagnostiqué un carcinome du poumon non à petites cellules. Plus spécifiquement, la présente invention concerne des méthodes qui mesurent l'activité kinase en étudiant les niveaux et les profils de phosphorylation et leurs inhibitions par des médicaments dans des échantillons sanguins desdits patients.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)