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1. (WO2019030240) ANTIBODIES BINDING TO A LINEAR HUMAN CS1 EPITOPE
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/030240 International Application No.: PCT/EP2018/071429
Publication Date: 14.02.2019 International Filing Date: 07.08.2018
IPC:
A61K 19/00
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
19
Medicinal preparations containing enzymes
Applicants:
NBE-THERAPEUTICS AG [CH/CH]; Hochbergerstr. 60C 4057 Basel, CH
THE SCRIPPS RESEARCH INSTITUTE [US/US]; 10550 North Torrey Pines Road La Jolla, California 92037, US
Inventors:
HELLMANN, Ina; FR
BEERLI, Roger; CH
GRAWUNDER, Ulf; CH
RADER, Christoph; US
HAIYONG, Peng; US
Agent:
MICHALSKI HÜTTERMANN & PARTNER, PATENTANWÄLTE MBB; Speditionstr. 21 40221 Düsseldorf, DE
DR. STORZ, Ulrich; DE
Priority Data:
17185107.407.08.2017EP
Title (EN) ANTIBODIES BINDING TO A LINEAR HUMAN CS1 EPITOPE
(FR) ANTICORPS SE LIANT À UN ÉPITOPE CS1 HUMAIN LINÉAIRE
Abstract:
(EN) An antibody or antigen-binding fragment thereof, or a chimeric antigen receptor (CAR), which competes for binding to a linear human CS1 epitope comprising an amino acid sequence according to SEQ ID NO. 1 with an antibody having a heavy chain/light chain amino acid sequence pair according to any one selected from the following pairs SEQ ID NO. 3 / SEQ ID NO. 4; SEQ ID NO. 5 / SEQ ID NO. 6; SEQ ID NO. 7 / SEQ ID NO. 8; SEQ ID NO. 9 / SEQ ID NO. 10; SEQ ID NO. 11/ SEQ ID NO. 12; SEQ ID NO. 13/ SEQ ID NO. 14, and/or SEQ ID NO. 15 / SEQ ID NO. 16.
(FR) L'invention concerne un anticorps ou un fragment de liaison à l'antigène de celui-ci, ou un récepteur d'antigène chimère (CAR), qui est en concurrence pour se lier à un épitope CS1 humain linéaire comprenant une séquence d'acides aminés selon SEQ ID NO : 1 avec un anticorps ayant une paire de séquences d'acides aminés de chaîne lourde/chaîne légère selon l'une quelconque choisie parmi les paires suivantes SEQ ID NO : 3 / SEQ ID NO : 4 ; SEQ ID NO : 5 / SEQ ID NO : 6 ; SEQ ID NO : 7 / SEQ ID NO : 8 ; SEQ ID NO : 9 / SEQ ID NO : 10 ; SEQ ID NO : 11/ SEQ ID NO : 12 ; SEQ ID NO : 13/ SEQ ID NO : 14, et/ou SEQ ID NO : 15 / SEQ ID NO : 16.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)