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1. (WO2019029715) COMPOUNDS AND METHODS FOR THE TREATMENT OF TROP2 POSITIVE DISEASES
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/029715 International Application No.: PCT/CN2018/100011
Publication Date: 14.02.2019 International Filing Date: 10.08.2018
IPC:
C07K 16/30 (2006.01) ,A61K 31/5365 (2006.01) ,A61K 47/68 (2017.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5365
ortho- or peri-condensed with heterocyclic ring systems
[IPC code unknown for A61K 47/68]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
BIO-THERA SOLUTIONS, LTD. [CN/CN]; Enterprise Accelerateor A6-5fl. 11Kaiyuan Rd., Science City Guangzhou, Guangdong 510530, CN
Inventors:
TANG, Weijia; CN
HUANG, Xiaoyang; CN
YU, Jin-Chen; CN
OU, Ziqiang; CN
PENG, Xian; CN
YANG, Yili; CN
LI, Shengfeng; CN
QIN, Chao; CN
Agent:
BEIJING WANHUIDA LAW FIRM; 2F, Yiyuan Office, Friendship Hotel No. 1 Zhongguancun Street South, Haidian District Beijing 100873, CN
Priority Data:
201710687161.611.08.2017CN
Title (EN) COMPOUNDS AND METHODS FOR THE TREATMENT OF TROP2 POSITIVE DISEASES
(FR) COMPOSÉS ET MÉTHODES DE TRAITEMENT DES MALADIES TROP2 POSITIVES
Abstract:
(EN) Disclosed herein are anti-TROP2 antibodies conjugated with maytansinoid drugs for targeted delivery to disease tissues. Methods relating to the preparation and uses of such drug conjugates to treat TROP2 positive cells in cancers are provided.
(FR) L'invention concerne des anticorps anti-TROP2 conjugués à des médicaments maytansinoïdes pour l'administration ciblée dans des tissus malades. L'invention concerne également des méthodes relatives à la préparation et aux utilisations de ces conjugués médicamenteux pour traiter les cancers à cellules TROP2 positives.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2018267660EP3464381CA3038423