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1. (WO2019029620) ATX INHIBITORS, PREPARATION METHOD THEREFOR AND APPLICATIONS THEREOF
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/029620 International Application No.: PCT/CN2018/099622
Publication Date: 14.02.2019 International Filing Date: 09.08.2018
IPC:
C07D 487/04 (2006.01) ,C07D 519/00 (2006.01) ,A61K 31/4985 (2006.01) ,A61K 31/5025 (2006.01) ,A61P 35/00 (2006.01) ,A61P 37/00 (2006.01) ,A61P 29/00 (2006.01) ,A61P 25/28 (2006.01) ,A61P 9/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
519
Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985
Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50
Pyridazines; Hydrogenated pyridazines
5025
ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
Applicants:
广州市恒诺康医药科技有限公司 GUANGZHOU HENOVCOM BIOSCIENCE CO., LTD [CN/CN]; 中国广东省广州市 黄埔区开源大道11号C4栋第九层 9F, Zone C4, 11 Kaiyuan Road, HuangPu District Guangzhou, Guangdong 510535, CN
Inventors:
张健存 ZHANG, Jiancun; CN
邹晴安 ZOU, Qingan; CN
林财 LIN, Cai; CN
陈延维 CHEN, Yanwei; CN
张礼军 ZHANG, Lijun; CN
Agent:
北京瑞恒信达知识产权代理事务所(普通合伙) LEADING INTELLECTUAL PROPERTY FIRM; 中国北京市 海淀区大柳树路17号富海中心2号楼9层909房间 Room 909, 9th Floor, Tower B, Fortune Building, No. 17, Daliushu Road, Haidian District Beijing 100081, CN
Priority Data:
201710676599.409.08.2017CN
Title (EN) ATX INHIBITORS, PREPARATION METHOD THEREFOR AND APPLICATIONS THEREOF
(FR) INHIBITEUR D'ATX, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) ATX抑制剂及其制备方法和应用
Abstract:
(EN) Provided is a compound of formula I with an ATX inhibitory activity and the application thereof in preparing drugs for treating ATX related diseases.
(FR) Fait l'objet de la présente invention un composé de formule I à activité inhibitrice d'ATX ainsi que son application dans la préparation d'un médicament pour le traitement ou la prévention de maladies associées à ATX.
(ZH) 提供了具有ATX抑制活性的式I化合物以及在制备治疗与ATX相关疾病的药物中的用途。
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)