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1. (WO2019029554) SULFONAMIDE DERIVATIVE, PREPARATION METHOD THEREOF, AND USE OF SAME IN MEDICINE
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/029554 International Application No.: PCT/CN2018/099333
Publication Date: 14.02.2019 International Filing Date: 08.08.2018
IPC:
C07D 471/04 (2006.01) ,A61K 31/407 (2006.01) ,A61K 31/437 (2006.01) ,A61P 31/00 (2006.01) ,A61P 31/18 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
407
condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
18
for HIV
Applicants:
浙江海正药业股份有限公司 ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. [CN/CN]; 中国浙江省台州市 椒江区外沙路46号 No. 46 Waisha Road, Jiaojiang District Taizhou, Zhejiang 318000, CN
Inventors:
吕贺军 LV, Hejun; CN
赵雯雯 ZHAO, Wenwen; CN
王成喜 WANG, Chengxi; CN
陈磊 CHEN, Lei; CN
Agent:
北京集佳知识产权代理有限公司 UNITALEN ATTORNEYS AT LAW; 中国北京市 朝阳区建国门外大街22号赛特广场7层 7th Floor, Scitech Place No. 22, Jian Guo Men Wai Ave., Chao Yang District Beijing 100004, CN
Priority Data:
201710680178.910.08.2017CN
Title (EN) SULFONAMIDE DERIVATIVE, PREPARATION METHOD THEREOF, AND USE OF SAME IN MEDICINE
(FR) DÉRIVÉ SULFONAMIDE, SA MÉTHODE DE PRÉPARATION ET SON APPLICATION EN MÉDECINE
(ZH) 磺酰胺类衍生物、其制备方法及其在医药上的用途
Abstract:
(EN) The present invention relates to a sulfonamide derivative and a preparation method and medical use thereof. In particular, the present invention relates to a sulfonamide derivative shown in formula (I), a preparation method and pharmaceutically acceptable salt thereof, and a use of the same as a therapeutic agent, especially as a bromodomain protein inhibitor. The definition of each substituent in formula (I) is the same as the definition in the specification.
(FR) La présente invention concerne un nouveau dérivé sulfonamide, un procédé pour sa préparation et son utilisation en médicine. En particulier, la présente invention concerne un dérivé sulfonamide représenté par la formule (I), un procédé de préparation et un sel pharmaceutiquement acceptable de celui-ci, et une utilisation de celui-ci en tant qu'agent thérapeutique, en particulier en tant qu'inhibiteur de protéine de bromodomaine. La définition de chaque substituant dans la formule générale (I) est la même que celle donnée dans la description.
(ZH) 涉及磺酰胺类衍生物及其制备方法和医药用途。具体而言,涉及式(I)所示的磺酰胺类衍生物、其制备方法及其可药用的盐,以及它们作为治疗剂,特别是作为溴结构域蛋白抑制剂的用途,其中式(I)中的各取代基的定义与说明书中的定义相同。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)