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1. (WO2019029521) DIARYLTHIOHYDANTOIN COMPOUND AS ANDROGEN RECEPTOR ANTAGONIST
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/029521 International Application No.: PCT/CN2018/099161
Publication Date: 14.02.2019 International Filing Date: 07.08.2018
IPC:
C07D 403/04 (2006.01) ,C07D 491/107 (2006.01) ,C07D 471/04 (2006.01) ,A61K 31/4178 (2006.01) ,A61K 31/4184 (2006.01) ,A61P 35/00 (2006.01) ,A61P 19/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
10
Spiro-condensed systems
107
with only one oxygen atom as ring hetero atom in the oxygen-containing ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4178
not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4184
condensed with carbocyclic rings, e.g. benzimidazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
Applicants:
正大天晴药业集团股份有限公司 CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. [CN/CN]; 中国江苏省连云港市 郁州南路369号 No. 369 Yuzhou South Rd. Lianyungang, Jiangsu 222062, CN
南京明德新药研发股份有限公司 MEDSHINE DISCOVERY INC. [CN/CN]; 中国江苏省南京市 高新开发区高新路9号商务办公楼218室 Room 218 No.9 Gaoxin Road Gaoxin Development District Nanjing, Jiangsu 210032, CN
Inventors:
沈春莉 SHEN, Chunli; CN
吴成德 WU, Chengde; CN
陈胜林 CHEN, Shenglin; CN
陈曙辉 CHEN, Shuhui; CN
张喜全 ZHANG, Xiquan; CN
田心 TIAN, Xin; CN
Agent:
北京英赛嘉华知识产权代理有限责任公司 INSIGHT INTELLECTUAL PROPERTY LIMITED; 中国北京市 海淀区知春路甲48号盈都大厦A座19A 19 A, Tower A, InDo Building No. 48A Zhichun Road, Haidian District Beijing 100098, CN
Priority Data:
201710667860.407.08.2017CN
201810333652.513.04.2018CN
Title (EN) DIARYLTHIOHYDANTOIN COMPOUND AS ANDROGEN RECEPTOR ANTAGONIST
(FR) COMPOSÉ DIARYLTHIOHYDANTOÏNE UTILISÉ EN TANT QU'ANTAGONISTE DU RÉCEPTEUR DES ANDROGÈNES
(ZH) 用作雄激素受体拮抗剂的二芳基硫代乙内酰脲化合物
Abstract:
(EN) The present application belongs to the field of medicine. In particular, the present application relates to a diarylthiohydantoin compound as an androgen receptor antagonist or a pharmaceutically acceptable salt thereof, a preparation method of the same, a pharmaceutical composition comprising the compound, and a use thereof in treating a cell proliferative disease mediated by androgen. The compound of the present application has good antagonistic effect on androgen receptor and exhibits excellent antitumor effect.
(FR) La présente invention se rapporte au domaine de la médecine. En particulier, la présente invention concerne un composé diarylthiohydantoïne en tant qu'antagoniste du récepteur des androgènes ou un sel pharmaceutiquement acceptable de celui-ci, un procédé de préparation de celui-ci, une composition pharmaceutique comprenant le composé, et une utilisation de celui-ci dans le traitement d'une maladie proliférative cellulaire à médiation par l'androgène. Le composé selon la présente invention a un bon effet antagoniste sur le récepteur des androgènes et présente un excellent effet antitumoral.
(ZH) 本申请属于医药领域,具体而言涉及用作雄激素受体拮抗剂的二芳基硫代乙内酰脲化合物或其药学上可接受的盐、其制备方法、含有该化合物的药物组合物、以及其在治疗雄激素介导的细胞增殖性疾病中的用途。本申请的化合物具有良好的雄激素受体拮抗作用,表现出优异的抗肿瘤效果。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)