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1. (WO2019029477) CRYSTAL FORM OF DIMALEATE OF TYROSINE KINASE INHIBITOR AND PREPARATION METHOD THEREFOR
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/029477 International Application No.: PCT/CN2018/098950
Publication Date: 14.02.2019 International Filing Date: 06.08.2018
IPC:
C07D 401/14 (2006.01) ,A61K 31/4709 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4709
Non-condensed quinolines containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
江苏恒瑞医药股份有限公司 JIANGSU HENGRUI MEDICINE CO., LTD. [CN/CN]; 中国江苏省连云港市 经济技术开发区昆仑山路7号 No.7 Kunlunshan Road, Economic and Technological Development Zone Lianyungang, Jiangsu 222047, CN
Inventors:
曹笑立 CAO, Xiaoli; CN
王立坤 WANG, Likun; CN
杜振兴 DU, Zhenxing; CN
Agent:
北京戈程知识产权代理有限公司 GE CHENG & CO., LTD.; 中国北京市 东城区东长安街1号东方广场东三办公楼19层程伟(David W. CHENG) David W. CHENG Level 19, Tower E3, the Towers, Oriental Plaza, No.1, East Chang An Avenue, Dongcheng District Beijing 100738, CN
Priority Data:
201710667478.307.08.2017CN
Title (EN) CRYSTAL FORM OF DIMALEATE OF TYROSINE KINASE INHIBITOR AND PREPARATION METHOD THEREFOR
(FR) FORME CRISTALLINE DE DIMÉALATE D'INHIBITEUR DE TYROSINE KINASE ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 一种酪氨酸激酶抑制剂的二马来酸盐的晶型及其制备方法
Abstract:
(EN) The present invention relates to a crystal form of a dimaleate of a tyrosine kinase inhibitor and a preparation method therefor. Specifically, the present invention relates to a crystal form IV of a dimaleate of an epidermal growth factor receptor (EGFR) inhibitor and a preparation method therefor. The crystal form IV has good chemical stability and crystal form stability and may be better used in clinical treatment.
(FR) La présente invention concerne une forme cristalline de diméalate d'un inhibiteur de tyrosine kinase et un procédé de préparation correspondant. De manière plus spécifique, la présente invention concerne une forme cristalline IV de diméalate d'un inhibiteur de facteur de croissance épidermique (EGFR) et un procédé de préparation correspondant. La forme cristalline IV présente une bonne stabilité chimique et une bonne stabilité de forme cristalline et peut être mieux utilisée dans un traitement clinique.
(ZH) 本发明涉及一种酪氨酸激酶抑制剂的二马来酸盐的晶型及其制备方法。具体而言,本发明涉及一种表皮生长因子受体(EGFR)抑制剂的二马来酸盐的Ⅳ晶型及其制备方法。该Ⅳ晶型具备良好的化学稳定性和晶型稳定性,可更好地用于临床治疗。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)