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1. (WO2019029319) COMPOSITE PRODUCT CONTAINING LIMONIN COMPOUND AND BIGUANIDE COMPOUND
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/029319 International Application No.: PCT/CN2018/095615
Publication Date: 14.02.2019 International Filing Date: 13.07.2018
IPC:
A61K 31/155 (2006.01) ,A61K 31/366 (2006.01) ,C07J 73/00 (2006.01) ,A61P 3/10 (2006.01) ,A61P 3/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
155
Amidines (), e.g. guanidine (H2N-C(NH)-NH2), isourea (HNC(OH)NH2), isothiourea (HNC(SH)-NH2)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
365
Lactones
366
having six-membered rings, e.g. delta-lactones
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
73
Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
Applicants:
浙江养生堂天然药物研究所有限公司 ZHEJIANG YANGSHENGTANG INSTITUTE OF NATURAL MEDICATION CO., LTD. [CN/CN]; 中国浙江省杭州市 西湖区转塘街道葛衙庄181号 No.181 Geyazhuang, Zhuantang Street, Xihu District Hangzhou, Zhejiang 310024, CN
Inventors:
李栋 LI, Dong; CN
韩铨 HAN, Quan; CN
胡柳 HU, Liu; CN
薛莲 XUE, Lian; CN
Agent:
中国国际贸易促进委员会专利商标事务所 CCPIT PATENT AND TRADEMARK LAW OFFICE; 中国北京市 西城区阜成门外大街2号万通新世界广场8层 8th Floor, Vantone New World Plaza 2 Fuchengmenwai Street Xicheng District, Beijing 100037, CN
Priority Data:
201710670354.008.08.2017CN
Title (EN) COMPOSITE PRODUCT CONTAINING LIMONIN COMPOUND AND BIGUANIDE COMPOUND
(FR) PRODUIT COMPOSITE CONTENANT UN COMPOSÉ DE LIMONINE ET UN COMPOSÉ DE BIGUANIDE
(ZH) 包含柠檬苦素类化合物和双胍类化合物的组合产品
Abstract:
(EN) The present invention relates to a composition containing a limonin compound and a pharmaceutically acceptable derivative, ester, stereoisomer, salt or prodrug thereof and a biguanide compound; the biguanide compound may be metformin or metformin hydrochloride, buformin or phenformin, and so on. The present invention further relates to a use of the composition in the treatment and/or prevention of diseases associated with diabetes, fat-reduction weight loss and so on.
(FR) La présente invention concerne une composition contenant un composé de limonine et un dérivé, ester, stéréoisomère, sel ou promédicament de qualité pharmaceutique de ce dernier, et un composé de biguanide; le composé de biguanide peut être de la metformine ou du chlorhydrate de metformine, de la buformine ou de la phenformine, et ainsi de suite. La présente invention concerne en outre une utilisation de la composition dans le traitement et/ou la prévention de maladies associées au diabète, à la perte de poids par réduction de graisse, et ainsi de suite.
(ZH) 本发明涉及一种含有柠檬苦素类化合物以及其药学上可接受的衍生物、酯、立体异构体、盐或前药和双胍类化合物的组合物,其中的双胍类化合物可以是二甲双胍、盐酸二甲双胍、丁双胍或苯乙双胍等。本发明还涉及该组合物在治疗和/或预防与糖尿病相关疾病和降脂减肥等方面的用途。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)