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1. (WO2019029274) 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND AND PREPARATION METHOD THEREFOR
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/029274 International Application No.: PCT/CN2018/091962
Publication Date: 14.02.2019 International Filing Date: 20.06.2018
IPC:
C07D 207/38 (2006.01) ,C07D 401/12 (2006.01) ,C07D 409/12 (2006.01) ,A61P 25/28 (2006.01) ,A61P 25/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30
having two double bonds between ring members or between ring members and non-ring members
34
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36
Oxygen or sulfur atoms
38
2-Pyrrolones
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
Applicants:
北京卓凯生物技术有限公司 BEIJING JOEKAI BIOTECH. LLC [CN/CN]; 中国北京市 海淀区永捷北路9号1幢4F401室杜书文 DU, Shuwen 401 Rm., 1st Building, No. 9 Yongjie North Rd., Haidian District Beijing 100094, CN
Inventors:
杜书文 DU, Shuwen; CN
谢作磊 XIE, Zuolei; CN
Agent:
北京纪凯知识产权代理有限公司 JEEKAI & PARTNERS; 中国北京市 丰台区广安路9号5号楼15A层 Floor 15A, Building No. 5, 9 Guang'an Road, Fengtai District Beijing 100055, CN
Priority Data:
201710684334.911.08.2017CN
Title (EN) 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND AND PREPARATION METHOD THEREFOR
(FR) COMPOSÉ D'ACIDE TÉTRAMIQUE 4-OXO-ALKYLÉ ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 4-氧-烷基化特特拉姆酸类化合物及其制备方法
Abstract:
(EN) Provided in the present invention are a novel compound and a preparation method therefor. The general structural formula of the compound is shown as formula I. Animal experiments prove that the compound of the present invention has the effect of saving the memories of animal models, is highly safe, has no mutagenicity, may remain in blood for several hours after oral administration and intravenous injection, may enter the brain and may be used to prepare drugs for treating Alzheimer's disease.
(FR) La présente invention concerne un nouveau composé et son procédé de préparation. La formule structurelle générale du composé est représentée par la formule I, des expériences sur animaux prouvent que le composé selon la présente invention a pour effet de sauvegarder les mémoires de modèles animaux, ledit composé est sans danger, ne présente pas de mutagénicité, peut rester dans le sang pendant plusieurs heures après administration orale et injection intraveineuse, peut pénétrer dans le cerveau et peut être utilisé pour préparer des médicaments destinés au traitement de la maladie d'Alzheimer.
(ZH) 本发明提供了一类新型化合物及其制备方法,结构通式如式I所示,经动物实验验证,本发明化合物具有挽救动物模型记忆的效果,安全性高,不具有致诱变性,口服和静脉注射后均能在血液中停留数个小时,并能进入大脑,可用于制备治疗老年痴呆病的药物。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)