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1. (WO2019028937) APPLICATIONS OF EUGENOL/CLOVE OIL IN INHIBITING ORAL CONDITIONAL PATHOGENIC BACTERIA
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/028937 International Application No.: PCT/CN2017/098568
Publication Date: 14.02.2019 International Filing Date: 23.08.2017
IPC:
A61K 31/085 (2006.01) ,A61K 36/61 (2006.01) ,A61P 1/02 (2006.01) ,A61P 31/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
075
Ethers or acetals
085
having an ether linkage to aromatic ring nuclear carbon
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
61
Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
02
Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
02
Local antiseptics
Applicants:
佛山科学技术学院 FOSHAN UNIVERSITY [CN/CN]; 中国广东省佛山市 禅城区江湾一路18号 No. 18, Jiangwan 1st Road, Chancheng District Foshan, Guangdong 528000, CN
Inventors:
杜卓 DU, Zhuo; CN
谭淑仪 TAN, Shuyi; CN
刘芳 LIU, Fang; CN
张丽华 ZHANG, Lihua; CN
林树辉 LIN, Shuhui; CN
Agent:
广州嘉权专利商标事务所有限公司 JIAQUAN IP LAW FIRM; 中国广东省广州市 天河区黄埔大道西100号富力盈泰广场A栋910张萍 ZHANG, Ping No. 910, Building A, Winner Plaza, No. 100, West Huangpu Avenue, Tianhe District Guangzhou, Guangdong 510627, CN
Priority Data:
201710670556.508.08.2017CN
Title (EN) APPLICATIONS OF EUGENOL/CLOVE OIL IN INHIBITING ORAL CONDITIONAL PATHOGENIC BACTERIA
(FR) APPLICATIONS D'HUILE DE CLOU DE GIROFLE/EUGÉNOL DANS L'INHIBITION DE BACTÉRIES PATHOGÈNES CONDITIONNELLES BUCCALES
(ZH) 丁香酚/丁香油在抑制口腔条件致病菌的应用
Abstract:
(EN) Applications of eugenol/clove oil in preparing a medicament for inhibiting oral conditional pathogenic bacteria. The oral conditional pathogenic bacteria comprise Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus albus, Staphylococcus citreus, group A streptococcus, group B streptococcus, and Candida albicans. A multiple dilution method is employed for the measurement of the minimum inhibitory concentration (MIC) of each bacterium. The minimum concentration of eugenol/clove oil without visible opacity in a liquid medium test tube to the naked eye is the MIC of the oral conditional pathogenic bacterium. With Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus albus, Staphylococcus citreus, group A streptococcus, group B streptococcus, and Candida albicans serving as objects, the MIC of eugenol/clove oil with respect to common conditional pathogenic bacteria in the oral cavity is observed, and the application value of same in terms of oral bacteriostasis and disinfection is observed. This favors an expanded scope of application for eugenol/clove oil.
(FR) L'invention concerne des applications d'huile de clou de girofle/eugénol dans la préparation d'un médicament pour inhiber des bactéries pathogènes conditionnelles buccales. Les bactéries pathogènes conditionnelles buccales comprennent Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus albus, Staphylococcus citreus, Streptococcus de groupe A, Streptococcus de groupe B, et Candida albicans. Un procédé de dilution multiple est utilisé pour mesurer la concentration inhibitrice minimale (MIC) de chaque bactérie. La concentration minimale en huile de clou de girofle/eugénol sans opacité visible dans un tube à essai de milieu liquide à l’œil nu est la MIC de la bactérie pathogène conditionnelle buccale. Avec Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus albus, Staphylococcus citreus, Streptococcus de groupe A, Streptococcus de groupe B, et Candida albicans servant d'objets, la MIC d'huile de clou de girofle/eugénol par rapport à des bactéries pathogènes conditionnelles communes dans la cavité buccale est observée, et la valeur d'application de celle-ci en termes de bactériostase et de désinfection buccales est observée. Ceci privilégie un champ d'application étendu de l'huile de clou de girofle/eugénol.
(ZH) 丁香酚/丁香油在制备抑制口腔条件致病菌药物中的应用,所述口腔条件致病菌包括绿脓杆菌、金黄色葡萄球菌、白色葡萄球菌、柠檬色葡萄球菌、甲型链球菌、乙型链球菌、白色念珠菌。采用倍数稀释法对各菌种进行最低抑菌浓度MIC的测定。液体培养基试管中无肉眼可见浑浊的丁香酚/丁香油最低浓度,即为该口腔条件致病菌最低抑菌浓度MIC。以绿脓杆菌、金黄色葡萄球菌、白色葡萄球菌、柠檬色葡萄球菌、甲型链球菌、乙型链球菌、白色念珠菌为对象,考察丁香酚/丁香油对口腔中常见条件致病菌的最低抑菌浓度,考察其在口腔抑菌消毒方面的应用价值。有利于扩大丁香酚/丁香油的应用范围。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)