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1. (WO2019028933) DRYOPTERIS FRAGRANS PHLOROGLUCINOL COMPOUND FLAVASPIDIC ACID BB AND ANTIBACTERIAL APPLICATION THEREOF
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/028933 International Application No.: PCT/CN2017/098215
Publication Date: 14.02.2019 International Filing Date: 21.08.2017
IPC:
A61K 31/122 (2006.01) ,A61P 31/04 (2006.01) ,C07C 46/00 (2006.01) ,C07C 50/38 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
12
Ketones
122
having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
46
Preparation of quinones
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
50
Quinones
38
containing -CHO or non-quinoid keto groups
Applicants:
广东药科大学 GUANGDONG PHARMACEUTICAL UNIVERSITY [CN/CN]; 中国广东省广州市 番禺区广州大学城外环东路280号 Panyu District No. 280 Outer Ring East Road, Guangzhou University City Guangzhou, Guangdong 510006, CN
Inventors:
沈志滨 SHEN, Zhibin; CN
Agent:
广州粤高专利商标代理有限公司 YOGO PATENT & TRADE MARK AGENCY LIMITED COMPANY; 中国广东省广州市 天河区体育西路191号中石化大厦B塔4416室 Room 4416, Block B, Sinopec Tower Tiyuxi Road, Tianhe District Guangzhou, Guangdong 510620, CN
Priority Data:
201710678388.409.08.2017CN
Title (EN) DRYOPTERIS FRAGRANS PHLOROGLUCINOL COMPOUND FLAVASPIDIC ACID BB AND ANTIBACTERIAL APPLICATION THEREOF
(FR) ACIDE FLAVASPIDIQUE BB DE COMPOSÉ DE PHLOROGLUCINOL DE DRYOPTERIS FRAGRANS ET SON APPLICATION À VISÉE ANTIBACTÉRIENNE
(ZH) 香鳞毛蕨间苯三酚类化合物黄绵马酸BB及其抗菌应用
Abstract:
(EN) The present invention relates to the technical field of pharmaceuticals, and discloses an antibacterial application of a Dryopteris fragrans phloroglucinol compound flavaspidic acid BB. The present invention provides for the first time a method of chemical synthesis to obtain a flavaspidic acid BB compound, which has good antibacterial applications and effectively remedies shortcomings in the application of natural antibacterial compounds, and particularly provides an effective antibacterial solution for drug-resistant bacteria. Experimental results showed that the compound obtained by the present invention has strong antibacterial effects, especially exhibiting good curative effects against drug-resistant bacteria.
(FR) La présente invention concerne le domaine technique des produits pharmaceutiques, et concerne l'application à visée antibactérienne d'un acide flavaspidique BB de composé de phloroglucinol de Dryopteris fragrans. Pour la première fois, la présente invention concerne un procédé de synthèse chimique permettant d'obtenir un composé d'acide flavaspidique BB, qui a de bonnes applications à visée antibactérienne et remédie efficacement aux inconvénients de l'application des composés antibactériens naturels, qui apporte en particulier une solution antibactérienne efficace dans le cas des bactéries résistant aux médicaments. Les résultats expérimentaux ont montré que le composé obtenu par la présente invention a de forts effets antibactériens, et fait preuve en particulier de bons effets curatifs contre les bactéries résistant aux médicaments.
(ZH) 本发明涉及医药技术领域,公开了一种香鳞毛蕨间苯三酚类化合物黄绵马酸BB的抗菌应用。本发明首次提供了化学合成的方法得到黄绵马酸BB化合物,其具有良好的抗菌应用,有效填补抗菌天然化合物的应用不足,尤其是针对耐药性细菌提供有效地抗菌解决方案。实验结果显示,本发明所得化合物具有较强的抗细菌作用,尤其是针对耐药性细菌,疗效良好。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)