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1. (WO2019028469) POLYMER-FUNCTIONALIZED MITOCHONDRIAL COMPOSITIONS AND METHODS OF USE IN CELLULAR TRANSPLANTATION AND FOR ALTERING METABOLIC PHENOTYPE
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Pub. No.: WO/2019/028469 International Application No.: PCT/US2018/045416
Publication Date: 07.02.2019 International Filing Date: 06.08.2018
IPC:
A61P 3/00 (2006.01) ,A61K 38/17 (2006.01) ,A61K 48/00 (2006.01) ,A61K 35/12 (2015.01) ,A61K 47/69 (2017.01) ,A61P 9/00 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
[IPC code unknown for A61K 47/69]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
THE METHODIST HOSPITAL [US/US]; 6565 Fannin, MS D-200 Houston, Texas 77030, US
Inventors:
HAMILTON, Dale James; US
GUPTE, Anisha Anil; US
ZHANG, Aijun; US
BLANCO, Elvin; US
Agent:
MOORE, Mark D.; US
Priority Data:
62/541,64704.08.2017US
Title (EN) POLYMER-FUNCTIONALIZED MITOCHONDRIAL COMPOSITIONS AND METHODS OF USE IN CELLULAR TRANSPLANTATION AND FOR ALTERING METABOLIC PHENOTYPE
(FR) COMPOSITIONS MITOCHONDRIALES A POLYMÈRE FONCTIONNALISÉ ET PROCÉDÉS D'UTILISATION DANS UNE TRANSPLANTATION CELLULAIRE ET POUR MODIFIER UN PHÉNOTYPE MÉTABOLIQUE
Abstract:
(EN) Disclosed are methods and compositions including polymer-functionalized mammalian mitochondria, useful in a variety of therapeutic regimens for delivery of desirable genetic traits to one or more cells, tissues, and/or organs of interest. Also provided are methods for introducing mitochondria into selected host cells for altering the metabolic phenotype of such host cells using one or more mitochondrially-delivered nucleic acid molecules. The present disclosure is also directed to a method of cellular transplantation, comprising the step of administering to an individual one or more of the polymer functionalized mitochondrial compositions and formulations thereof as described herein.
(FR) L'invention concerne des procédés et des compositions comprenant des mitochondries mammaliennes à polymère fonctionnalisé, utiles dans une variété de régimes thérapeutiques pour l'administration de traits génétiques souhaitables à une ou à plusieurs cellules, tissus et/ou organes d'intérêt. L'invention concerne également des procédés d'introduction de mitochondries dans des cellules hôtes sélectionnées pour modifier le phénotype métabolique de telles cellules hôtes à l'aide d'une ou de plusieurs molécules d'acide nucléique délivrées de manière mitochondriale. La présente invention concerne également un procédé de transplantation cellulaire, comprenant l'étape consistant à administrer à un individu une ou plusieurs des compositions mitochondriales à polymère fonctionnalisé et des formulations de celles-ci telles que décrites dans la description.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)