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1. (WO2019028457) INJECTABLE DIETHYLSTILBESTROL NANOSUSPENSION FORMULATION
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Pub. No.: WO/2019/028457 International Application No.: PCT/US2018/045362
Publication Date: 07.02.2019 International Filing Date: 06.08.2018
IPC:
A61K 9/50 (2006.01) ,A61K 9/51 (2006.01) ,A61K 9/10 (2006.01) ,A61K 9/00 (2006.01) ,A61K 31/05 (2006.01) ,A61K 45/06 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
51
Nanocapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05
Phenols
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
UNIVERSITY OF HOUSTON SYSTEM [US/US]; 4800 Calhoun Road Houston, TX 77004, US
BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th Street Austin, TX 78701, US
Inventors:
CHOW, Diana, S-L; US
SAMANT, Tanay, S.; US
TU, Shi-Ming; US
Agent:
AMINI, Farhang; US
Priority Data:
62/541,54004.08.2017US
Title (EN) INJECTABLE DIETHYLSTILBESTROL NANOSUSPENSION FORMULATION
(FR) FORMULATION D'UNE NANOSUSPENSION DE DIÉTHYLSTILBESTROL INJECTABLE
Abstract:
(EN) Embodiments of the present disclosure pertain to formulations for cancer treatment that include a particle loaded with diethylstilbestrol (DES) and a pharmaceutically acceptable carrier. The pharmaceutically acceptable carrier may also be loaded into the particle. The formulations may also include a stabilizer that is also loaded into the particle. The particles may be dispersed in an aqueous solution to form a nanosuspension that is adapted for subcutaneous administration and sustained release of DES. Additional embodiments pertain to methods of treating cancer in a subject by administering to the subject a formulation of the present disclosure. The subject may be a human suffering from prostate cancer. The administration of the formulations to the subject may bypass or minimize first pass metabolism. The administration may also minimize hepatic exposure of DES. Additional embodiments pertain to methods of making the formulations of the present disclosure by loading a particle with DES.
(FR) Selon certains modes de réalisation, la présente divulgation concerne des formulations pour le traitement du cancer qui comprennent une particule chargée de diéthylstilbestrol (DES) et un véhicule pharmaceutiquement acceptable. Le véhicule pharmaceutiquement acceptable peut également être chargé dans la particule. Les formulations peuvent également comprendre un stabilisant qui est lui aussi chargé dans la particule. Les particules peuvent être dispersées dans une solution aqueuse pour former une nanosuspension qui se prête à une administration sous-cutanée et à une libération prolongée du DES. D'autres modes de réalisation concernent des méthodes de traitement du cancer chez un sujet par administration au sujet d'une formulation selon la présente divulgation. Le sujet peut être un sujet humain souffrant d'un cancer de la prostate. L'administration des formulations au sujet peut contourner ou réduire au minimum le métabolisme de premier passage. L'administration peut également réduire au minimum l'exposition hépatique du DES. D'autres modes de réalisation concernent des procédés de préparation des formulations selon la présente divulgation par chargement d'une particule avec du DES.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)