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1. (WO2019028453) TEMPORALLY FEATHERED RADIATION THERAPY
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What is claimed is:

1. A system comprising:

a non-transitory memory storing instructions; and

a processor configured to execute the instructions to:

determine a target volume for a radiation procedure based on at least one image, wherein the radiation procedure comprises a total dose of radiation to be administered in a time period;

determine an organ outside of the target volume at risk of acute toxicity from the radiation procedure based on the at least one image; and

construct a sequence plan that ensures the total dose of radiation is administered in the time period, wherein the sequence plan comprises one day of a high fractional dose of radiation and remaining days in the time period of a low fractional dose of radiation.

2. The system of claim 1 , wherein the sequence plan is sent to a computing device associated with a radiation delivery device,

wherein the radiation delivery device delivers the total dose of radiation to a patient associated with the target volume according to the sequence plan.

3. The system of claim 1 , wherein the processor is configured to determine a second organ outside the target volume at risk of acute toxicity from the radiation procedure based on the at least one image; and

construct a second sequence plan that ensure the total dose of radiation is administered in a second time period, wherein the second sequence plan comprises one day of a high fractional dose of radiation and four days of a low fractional dose of radiation delivered at a different distribution than the first sequence plan.

4. The system of claim 3, wherein the processor is configured to determine a third organ outside the target volume at risk of acute toxicity from the radiation procedure based on the at least one image; and

construct a third sequence plan that ensure the total dose of radiation is administered in a third time period, wherein the third sequence plan comprises one day of a high fractional dose of radiation and four days of a low fractional dose of radiation delivered at another different distribution than the first sequence plan and the second sequence plan.

5. The system of claim 1 , wherein the sequence plan is constructed to reduce the risk of acute toxicity in the organ outside of the target volume while still delivering the total dose of radiation to the target volume.

6. The system of claim 1 , wherein the target volume comprises malignant cells.

7. The system of claim 1 , wherein the high fractional dose of radiation is greater than 1 /5 times the total dose of radiation to be administered in the time period and the low fractional dose of radiation is less than 1 /5 times the total dose of radiation.

8. The system of claim 7, wherein the high fractional dose of radiation and the low fractional dose of radiation are chosen based on a recovery rate of the organ outside of the target volume from acute toxicity.

9. The system of claim 1 , wherein the total dosage is greater than a uniform total dosage delivered to the target area according to a sequence plan of uniform fractional doses of radiation.

10. A method comprising:

receiving, by a system comprising a processor, a radiation procedure comprising a total dose of radiation to be administered in a time period;

determining, by the system, a target volume for the radiation procedure based on at least one image;

determining, by the system, an organ outside of the target volume at risk of acute toxicity from the radiation procedure based on the at least one image; and

constructing, by the system, a sequence plan that ensures the total dose of radiation is administered in the time period, wherein the sequence plan comprises one day of a high fractional dose of radiation and remaining days of the time period a low fractional dose of radiation.

1 1 . The method of claim 10, further comprising sending, by the system, the sequence plan to a computing device associated with a radiation delivery device, wherein the radiation delivery device delivers the total dose of radiation to a patient associated with the target volume according to the sequence plan.

12. The method of claim 10, further comprising displaying, by the system, a graphical representation of the sequence plan on a graphical display device.

13. The method of claim 12, further comprising:

receiving, by the system, a confirmation of the sequence plan from an input device; and

upon receiving the confirmation, saving, by the system, the sequence plan for use in the radiation procedure.

14 The method of claim 10, further comprising:

determining, by a system, a second organ outside the target volume at risk of acute toxicity from the radiation procedure based on the at least one image; and constructing, by the system, a second sequence plan that ensure the total dose of radiation is administered in a second time period, wherein the second sequence plan comprises one day of a high fractional dose of radiation and four days of a low fractional dose of radiation delivered at a different distribution than the first sequence plan.

15. The method of claim 14, further comprising:

determining, by the system, a third organ outside the target volume at risk of acute toxicity from the radiation procedure based on the at least one image; and

constructing, by the system, a third sequence plan that ensure the total dose of radiation is administered in a third time period, wherein the third sequence plan comprises one day of a high fractional dose of radiation and four days of a low fractional dose of radiation delivered at another different distribution than the first sequence plan and the second sequence plan.

16. The method of claim 10, wherein the sequence plan is constructed to reduce the risk of acute toxicity in the organ outside of the target volume while still delivering the total dose of radiation to the target volume.

17. The method of claim 10, wherein the target volume comprises malignant cells.

18. The method of claim 10, wherein the high fractional dose of radiation is greater than 1/5 times the total dose of radiation to be administered in the time period and the low fractional dose of radiation is less than 1 /5 times the total dose of radiation.

19. The method of claim 18, wherein the high fractional dose of radiation and the low fractional dose of radiation are chosen based on a recovery rate of the organ outside of the target volume from acute toxicity.

20. The method of claim 10, wherein the total dosage is greater than a uniform total dosage delivered to the target area according to a sequence plan of uniform fractional doses of radiation.