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1. (WO2019028445) DEVICES AND METHODS FOR SEPARATING CIRCULATING TUMOR CELLS FROM BIOLOGICAL SAMPLES
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Pub. No.: WO/2019/028445 International Application No.: PCT/US2018/045294
Publication Date: 07.02.2019 International Filing Date: 04.08.2018
IPC:
G01N 3/00 (2006.01) ,G01N 15/10 (2006.01) ,G01N 33/574 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
3
Investigating strength properties of solid materials by application of mechanical stress
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15
Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
10
Investigating individual particles
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants:
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. [US/US]; 809 Boyd Graduate Studies Research Center 200 D. W. Brooks Drive Athens, Georgia 30602-7411, US
Inventors:
MAO, Leidong; US
Agent:
SEARS, John S.; US
Priority Data:
62/541,55204.08.2017US
Title (EN) DEVICES AND METHODS FOR SEPARATING CIRCULATING TUMOR CELLS FROM BIOLOGICAL SAMPLES
(FR) DISPOSITIFS ET PROCÉDÉS POUR SÉPARER DES CELLULES TUMORALES CIRCULANTES D’ÉCHANTILLONS BIOLOGIQUES
Abstract:
(EN) A variety of devices and methods are provided for separating or enriching circulating tumor cells in a biological sample such as whole blood. In some aspects, the devices are multi-stage devices including at least (i) a filtering stage, (ii) a sheath flow stage for ferrohydrodynamic separation of magnetically labelled white blood cells, and (iii) a focusing stage for markerindependent and size-independent focusing of magnetically labeled particles so as to separate or enrich unlabeled rare cells in the biological sample. The devices and methods are, in some aspects, capable of high throughput in excess of 6 milliliters per hour while achieving high separation (> 95%) of the unlabeled rare cells.
(FR) La présente invention concerne différents dispositifs et procédés pour séparer ou enrichir des cellules tumorales circulantes dans un échantillon biologique tel que du sang total. Dans certains aspects, les dispositifs sont des dispositifs à étages multiples comprenant au moins (i) un étage de filtrage, (ii) un étage d’écoulement de gaine pour la séparation ferrohydrodynamique de globules blancs magnétiquement marqués, et (iii) une étape de focalisation pour la focalisation indépendante du marqueur et indépendante de la taille de particules magnétiquement marquées de façon à séparer ou enrichir des cellules rares non marquées dans l’échantillon biologique. Les dispositifs et les procédés sont, dans certains aspects, capables d’atteindre un rendement élevé supérieur à 6 millilitres par heure tout en obtenant une séparation élevée (> 95 %) des cellules rares non marquées.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)