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1. (WO2019028417) B CELL RECEPTOR MODIFICATION IN B CELLS
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Pub. No.: WO/2019/028417 International Application No.: PCT/US2018/045255
Publication Date: 07.02.2019 International Filing Date: 03.08.2018
IPC:
C12N 15/63 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Applicants:
VOSS, James Even [US/US]; US
ANDRABI, Raiees [IN/US]; US
BURTON, Dennis R. [US/US]; US
HUANG, Deli [CN/US]; US
GONZALEZ-MARTIN, Alicia [ES/US]; US
THE SCRIPPS RESEARCH INSTITUTE [US/US]; 10550 North Torrey Pines Rd La Jolla, California 92037, US
Inventors:
VOSS, James Even; US
ANDRABI, Raiees; US
BURTON, Dennis R.; US
HUANG, Deli; US
GONZALEZ-MARTIN, Alicia; US
Agent:
PERDOK, Monique M.; US
ARORA, Suneel; US
BEEKMAN, Marvin L.; US
BIANCHI, Timothy E.; US
BLACK, David W.; US
SCHEER, Bradley W.; US
LANG, Roger; US
Priority Data:
62/540,70203.08.2017US
Title (EN) B CELL RECEPTOR MODIFICATION IN B CELLS
(FR) MODIFICATION DES RÉCEPTEURS DES LYMPHOCYTES B DANS LES LYMPHOCYTES B
Abstract:
(EN) Methods and systems are described herein for generating engineered B cells with modified immunoglobulin genes. The modified immunoglobulin genes encode modified immunoglobulins that can have high affinity for antigens, including antigens that are variable such the types of antigens on various pathogens that can escape mammalian immune responses.
(FR) L'invention concerne des procédés et des systèmes pour générer des lymphocytes B modifiés avec des gènes d'immunoglobulines modifiées. Les gènes d'immunoglobulines modifiées codent pour des immunoglobulines modifiées qui peuvent avoir une affinité élevée pour des antigènes, y compris des antigènes qui sont variables tels que les types d'antigènes présents sur divers agents pathogènes qui peuvent échapper aux réponses immunitaires des mammifères.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)