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1. (WO2019028382) METHOD OF CONJUGATION OF CYS-MABS
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Pub. No.: WO/2019/028382 International Application No.: PCT/US2018/045212
Publication Date: 07.02.2019 International Filing Date: 03.08.2018
IPC:
A61K 47/68 (2017.01) ,C07K 16/00 (2006.01) ,C07K 14/605 (2006.01)
[IPC code unknown for A61K 47/68]
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
575
Hormones
605
Glucagons
Applicants:
AMGEN INC. [US/US]; One Amgen Center Drive Thousand Oaks, California 91320-1799, US
Inventors:
ACHMATOWICZ, Michal; US
ROMANINI, Dante; US
FALSEY, James R.; US
HERBERICH, Bradley J.; US
THIEL, Oliver R.; US
Agent:
DERMOTT, Jonathan M.; US
Priority Data:
62/541,52204.08.2017US
Title (EN) METHOD OF CONJUGATION OF CYS-MABS
(FR) PROCÉDÉ DE CONJUGAISON DE CYS-MABS
Abstract:
(EN) The present disclosure relates to a method of capping, reducing, and oxidizing cys-mAbs in order to provide homogenous material for subsequent conjugation reactions. The present method demonstrates robust ways to manufacture conjugates of cysteine-engineered antibodies that offer high yield and consistent product quality.
(FR) La présente invention concerne un procédé de coiffage, de réduction et d'oxydation de cys-mAbs permettant de fournir un matériau homogène destiné à des réactions de conjugaison ultérieures. Le présent procédé met en évidence des façons fiables de fabrication de conjugués d'anticorps modifiés par cystéine qui offrent un rendement élevé et une qualité constante de produit.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)