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1. (WO2019028367) METHODS FOR TREATING ACTIVE EOSINOPHILIC ESOPHAGITIS
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Pub. No.: WO/2019/028367 International Application No.: PCT/US2018/045195
Publication Date: 07.02.2019 International Filing Date: 03.08.2018
IPC:
A61K 39/395 (2006.01) ,C07K 16/28 (2006.01) ,A61P 1/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
Applicants:
REGENERON PHARMACEUTICALS, INC. [US/US]; 777 Old Saw Mill River Road Tarrytown, New York 10591-6707, US
SANOFI BIOTECHNOLOGY; 54, rue La Boetie Paris 75008, FR
Inventors:
RADIN, Allen; US
HAMILTON, Jennifer D.; US
MANNENT, Leda; FR
Agent:
KOWALCHYK, Katherine, M.; US
KOWALCHYK, Katherine M.; US
HEUSCH, Marina I.; US
KROONA, Heather B.; US
BRUESS, Steven C.; US
SMITH, Ryan C.; US
Priority Data:
18305252.108.03.2018EP
62/541,24204.08.2017US
62/561,59321.09.2017US
Title (EN) METHODS FOR TREATING ACTIVE EOSINOPHILIC ESOPHAGITIS
(FR) MÉTHODES DE TRAITEMENT DE L'OESOPHAGITE À ÉOSINOPHILES ACTIVE
Abstract:
(EN) The present invention provides methods for treating, preventing or reducing the severity of active eosinophilic esophagitis. In certain embodiments, the present invention provides methods of increasing esophageal distensibility. The methods of the present invention comprise administering to a subject in need thereof a therapeutic composition comprising an interleukin-4/ interleukin-13 (IL-4/IL-13) pathway inhibitor such as an anti-IL-4R antibody.
(FR) La présente invention concerne des méthodes de traitement, de prévention ou de réduction de la gravité d'une œsophagite à éosinophiles active. Dans certains modes de réalisation, la présente invention concerne des procédés d'augmentation de la distension oesophagienne. Les méthodes de la présente invention comprennent l'administration à un sujet en ayant besoin d'une composition pharmaceutique comprenant un inhibiteur de la voie de l'interleukine 4-l'interleukine 13 (IL-4/IL-13) tel qu'un anticorps anti-IL-4R.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)