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1. (WO2019028340) FORMULATIONS COMPRISING A NUCLEIC ACID IN A HIGH CONCENTRATION
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Pub. No.: WO/2019/028340 International Application No.: PCT/US2018/045152
Publication Date: 07.02.2019 International Filing Date: 03.08.2018
IPC:
A61K 9/00 (2006.01) ,A61K 8/44 (2006.01) ,A61K 47/18 (2017.01) ,A61K 31/7088 (2006.01) ,A61K 9/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
18
characterised by the composition
30
containing organic compounds
40
containing nitrogen
44
Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts, esters or N-acylated derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
16
containing nitrogen
18
Amines; Quaternary ammonium compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
08
Solutions
Applicants:
DIMITROVA, Mariana [US/US]; US
BENNETT, William J. [US/US]; US
WANG, Qi [US/US]; US
JAZZ PHARMACEUTICALS IRELAND LIMITED [IE/IE]; Waterloo Exchange, 5th Floor Waterloo Road Dublin, 4, IE
Inventors:
DIMITROVA, Mariana; US
BENNETT, William J.; US
WANG, Qi; US
Agent:
FLECKENSTEIN, Anne E.; US
TUSCAN, Michael S.; US
VEITENHEIMER, Erich E.; US
Priority Data:
62/540,65703.08.2017US
Title (EN) FORMULATIONS COMPRISING A NUCLEIC ACID IN A HIGH CONCENTRATION
(FR) FORMULATIONS COMPRENANT UN ACIDE NUCLÉIQUE À HAUTE CONCENTRATION
Abstract:
(EN) Low-viscosity, high concentration nucleic acid compositions that can be administered by multiple parenteral routes may allow for less frequent dosing than nucleic acid products currently on the market. In particular, low-viscosity defibrotide formulations for subcutaneous, intramuscular, and intraperitoneal administration are more convenient to the patient and/or are administered outside of the hospital setting. Formulations of the invention may be used for the treatment of numerous conditions including for example, treatment of peripheral arteriopathies, treatment of acute renal insufficiency, treatment of acute myocardial ischemia, and treatment and prevention of sinusoidal obstruction syndrome or VOD.
(FR) Selon la présente invention, des compositions d'acide nucléique à haute concentration et faible viscosité, qui peuvent être administrées par de multiples voies parentérales, peuvent permettre un dosage moins fréquent que des produits d'acide nucléique actuellement sur le marché. En particulier, des formulations de défibrotide à faible viscosité pour administration sous-cutanée, intramusculaire et intrapéritonéale sont plus pratiques pour le patient et/ou peuvent être administrées hors du milieu hospitalier. Les formulations de l'invention peuvent être utilisées pour le traitement de nombreuses affections comprenant, par exemple, le traitement d'artériopathies périphériques, le traitement d'une insuffisance rénale aiguë, le traitement d'une ischémie myocardique aiguë et le traitement et la prévention du syndrome d'obstruction sinusoïdale, ou maladie veino-occlusive.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)