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1. (WO2019028302) SUBSTITUTED INDOLE COMPOUNDS USEFUL AS INHIBITORS OF TLR7/8/9
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/028302 International Application No.: PCT/US2018/045082
Publication Date: 07.02.2019 International Filing Date: 03.08.2018
IPC:
C07D 401/14 (2006.01) ,A61P 29/00 (2006.01) ,A61P 37/00 (2006.01) ,A61K 31/444 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
444
containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
Applicants:
BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road Princeton, New Jersey 08543, US
Inventors:
DYCKMAN, Alaric J.; US
DODD, Dharmpal S.; US
HAQUE, Tasir Shamsul; US
WHITELEY, Brian K.; US
GILMORE, John L.; US
Agent:
GREENBLATT, Gary D.; US
CLAUSS, Isabelle M.; US
DELAUNEY, Ashton J.; US
FARQUHARSON TORRES, Serena; US
GOLIAN, Paul D.; US
GUO, Z. Angela; US
HADAD, Henry; US
HAN, Bo; US
JACOBSEN, Barry; US
KORSEN, Elliott; US
LIU, Hong; US
PARLET, Nickki L.; US
SUN, Jing G.; US
VANATTEN, Mary; US
VOM WEGE, Julia; US
WALSH, Brian J.; US
EPPERSON, James; US
MINGO, Pamela A.; US
BELLOMY, Gregory R.; US
CHAO, Yuan; US
HAI, Bing; US
COULTER, Kathryn; US
Priority Data:
62/541,33504.08.2017US
Title (EN) SUBSTITUTED INDOLE COMPOUNDS USEFUL AS INHIBITORS OF TLR7/8/9
(FR) COMPOSÉS INDOLE SUBSTITUÉS UTILES EN TANT QU'INHIBITEURS DE TLR7/8/9
Abstract:
(EN) Disclosed are compounds of Formula (I) or a salt thereof, wherein: Y is Formula (II), or Formula (III); R1, R2, R2a, R2b, R2c, R3, R4,R5, m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
(FR) L'invention concerne des composés de formule (I) ou un sel de ceux-ci, dans laquelle : Y représente la formule (II), ou la formule (III) ; R1, R2, R2a, R2b, R2c, R3, R4,R5, m, et n sont tels que définis dans la description. L’invention concerne également des procédés d’utilisation de tels composés en tant qu’inhibiteurs de signalisation par le récepteur Toll-like 7, ou 8, ou 9 et des compositions pharmaceutiques comprenant de tels composés. Ces composés sont utiles dans le traitement de maladies inflammatoires et auto-immunes.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)