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1. (WO2019028301) [1,2,4]TRIAZOLO[4,3-a]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS
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Pub. No.: WO/2019/028301 International Application No.: PCT/US2018/045080
Publication Date: 07.02.2019 International Filing Date: 03.08.2018
IPC:
C07D 471/04 (2006.01) ,A61K 31/437 (2006.01) ,A61P 37/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
Applicants:
BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road Princeton, New Jersey 08543, US
Inventors:
DYCKMAN, Alaric J.; US
SHERWOOD, Trevor C.; US
Agent:
GREENBLATT, Gary D.; US
CLAUSS, Isabelle M.; US
DELAUNEY, Ashton J.; US
FARQUHARSON TORRES, Serena; US
GOLIAN, Paul D.; US
GUO, Z. Angela; US
HADAD, Henry; US
HAN, Bo; US
JACOBSEN, Barry; US
KORSEN, Elliott; US
LIU, Hong; US
PARLET, Nickki L.; US
SUN, Jing G.; US
VANATTEN, Mary; US
VOM WEGE, Julia; US
WALSH, Brian J.; US
EPPERSON, James; US
MINGO, Pamela A.; US
BELLOMY, Gregory R.; US
CHAO, Yuan; US
HAI, Bing; US
COULTER, Kathryn; US
Priority Data:
62/541,33104.08.2017US
Title (EN) [1,2,4]TRIAZOLO[4,3-a]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS
(FR) COMPOSÉS D'INDOLE SUBSTITUÉS PAR [1,2,4]TRIAZOLO[4,3-A] PYRIDINYLE
Abstract:
(EN) Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R2, R3, R4a, R4b, R4c, R4d, R5, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
(FR) L'invention concerne des composés de formule (I) ou un sel de ceux-ci, R1, R2, R3, R4a, R4b, R4c, R4d, R5, n, et p étant définis dans la description. L’invention concerne également des procédés d’utilisation de tels composés en tant qu’inhibiteurs de signalisation par le récepteur 7, ou 8, ou 9 de type Toll et des compositions pharmaceutiques comprenant de tels composés. Ces composés sont utiles dans le traitement de maladies inflammatoires et auto-immunes.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)