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1. (WO2019028281) OPTIMIZED PEPTIDES FOR TARGETING HUMAN NERVES AND THEIR USE IN IMAGE GUIDED SURGERY, DIAGNOSTICS AND THERAPEUTIC DELIVERY
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Pub. No.: WO/2019/028281 International Application No.: PCT/US2018/045054
Publication Date: 07.02.2019 International Filing Date: 02.08.2018
IPC:
A61K 47/64 (2017.01) ,A61K 38/16 (2006.01)
[IPC code unknown for A61K 47/64]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
Applicants:
NGUYEN, Quyen, T. [US/US]; US
WHITNEY, Mike [US/US]; US
HINGORANI, Dina [US/US]; US
TSIEN, Roger, Y. [US/US]; US
ADAMS, Stephen [US/US]; US
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin St., Twelfth Floor Oakland, CA 94607, US
Inventors:
NGUYEN, Quyen, T.; US
WHITNEY, Mike; US
HINGORANI, Dina; US
TSIEN, Roger, Y.; US
ADAMS, Stephen; US
Agent:
MACDOUGALL, Christina, A.; US
ESKER, Todd; US
LOVEYJOY, Brett, A.; US
EWAK, Byung, Cheol; US
ANTCZAK, Andrew, J.; US
Priority Data:
62/540,51002.08.2017US
62/659,61218.04.2018US
Title (EN) OPTIMIZED PEPTIDES FOR TARGETING HUMAN NERVES AND THEIR USE IN IMAGE GUIDED SURGERY, DIAGNOSTICS AND THERAPEUTIC DELIVERY
(FR) PEPTIDES OPTIMISÉS POUR LE CIBLAGE DE NERFS HUMAINS ET LEUR UTILISATION EN CHIRURGIE GUIDÉE PAR L'IMAGE, LES DIAGNOSTICS ET L'ADMINISTRATION D'AGENTS THÉRAPEUTIQUES
Abstract:
(EN) The present invention provides methods for guiding preservation of human neurons or human nerves during surgery by administering a fluorescently-labeled peptide that specifically binds to the human neurons or human nerves. The invention further provides human neuron or nerve targeting molecules comprising fluorescently-labeled peptides that specifically bind to human neurons or human nerves and compositions thereof.
(FR) La présente invention concerne des procédés de guidage contribuant à préserver les neurones ou les nerfs humains durant une intervention chirurgicale par administration d'un peptide marqué par fluorescence qui se lie spécifiquement aux neurones humains ou aux nerfs humains. Des molécules de ciblage de neurones ou de nerfs humains comprenant des peptides marqués par fluorescence qui se lient spécifiquement à des neurones humains ou des nerfs humains selon l'invention et des compositions les contenant sont en outre décrites.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)