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1. (WO2019028272) COMPOSITIONS AND METHODS FOR STABILIZING BENZOTHIAZOLE LUCIFERIN ANALOGS
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Pub. No.: WO/2019/028272 International Application No.: PCT/US2018/045040
Publication Date: 07.02.2019 International Filing Date: 02.08.2018
IPC:
C07D 417/04 (2006.01) ,C07D 253/06 (2006.01) ,C12Q 1/66 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
253
Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/166
02
not condensed with other rings
06
1,2,4-Triazines
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
66
involving luciferase
Applicants:
PROMEGA CORPORATION [US/US]; 2800 Woods Hollow Road Madison, WI 53711-5399, US
Inventors:
SHI, Ce; US
HALL, Mary, P.; US
KIRKLAND, Thomas, A.; US
ENCELL, Lance, P.; US
MEISENHEIMER, Poncho; US
ZHOU, Wenhui; US
Agent:
STAPLE, David W.; US
HOFMEISTER, Todd, S.; US
Priority Data:
62/541,35004.08.2017US
Title (EN) COMPOSITIONS AND METHODS FOR STABILIZING BENZOTHIAZOLE LUCIFERIN ANALOGS
(FR) COMPOSITIONS ET PROCÉDÉS DE STABILISATION D'ANALOGUES DE BENZOTHIAZOLE LUCIFÉRINE
Abstract:
(EN) Disclosed herein are compositions and methods for stabilizing a benzothiazole luciferin analog such as D-luciferin and 6-amino-D-luciferin. The compositions may include the benzothiazole luciferin analog, a thionucleobase compound of formula (I), and a liquid medium, in which the thionucleobase is present in an amount effective to stabilize the luminogenic composition against decomposition. The methods provided herein may stabilize the benzothiazole luciferin analog against decomposition by contacting the benzothiazole luciferin analog with an effective amount of the thionucleobase compound in the presence of a liquid medium. Also provided herein is a kit containing the composition.
(FR) La présente invention concerne des compositions et des procédés de stabilisation d'un analogue de benzothiazole luciférine tel qu'une D-luciférine et 6-amino-D-luciférine. Les compositions peuvent comprendre l'analogue de la benzothiazole luciférine, un composé thionucléobase de formule (I), et un milieu liquide, dans lequel la thionucléobase est présente en une quantité efficace pour stabiliser la composition luminogène vis-à-vis de la décomposition. Les procédés de l'invention peuvent stabiliser l'analogue de benzothiazole luciférine vis-à-vis de la décomposition en mettant en contact l'analogue de benzothiazole luciférine avec une quantité efficace du composé thionucléobase en présence d'un milieu liquide. La présente invention concerne également un kit contenant la composition.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)